Annals of Clinical Trials and Vaccines Research

Best Open Access Journals In Immunhistochemistry

 IHC is a superb detection technique and has the tremendous advantage of having the ability to point out exactly where a given protein is found within the tissue examined. It is also an effective way to examine the tissues. This has made it a widely used technique within the neurosciences, enabling researchers to look at protein expression within specific brain structures. For this reason, primary antibodies must be well-validated during a Western Blot or similar procedure. The technique is even more widely utilized in diagnostic surgical pathology for immunophenotyping tumors (e.g. immunostaining for e-cadherin to differentiate between DCIS (ductal carcinoma in situ: stains positive) and LCIS (lobular carcinoma in situ: doesn't stain positive). More recently, Immunohistochemical techniques are useful in differential diagnoses of multiple sorts of exocrine gland, head, and neck carcinomas. The diversity of IHC markers utilized in diagnostic surgical pathology is substantial. Many clinical laboratories in tertiary hospitals will have menus of over 200 antibodies used as diagnostic, prognostic and predictive biomarkers.  

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