Application Of Proteomics In Drug Desinging

‘Proteomics’ is the study of the proteome and involves the technology used to identify and quantify the various proteins, protein-protein and protein-nucleic acid interactions within the proteome, as well as the post-translational modifications that affect protein activity. Proteomic technologies with computational methods are advanced recently over many other complementary techniques. Proteomic approach of drug discovery includes finding an unstable protein that's causing an undesirable affect then usage of a molecule to switch its effect. Proteomics combines aspects of biology, chemistry, engineering and knowledge science and apply them to all or any areas of drug discovery. Introduction of safer, simpler and less expensive drugs are going to be the last word outcome of improvement of this technology. The development of proteomics will require the simultaneous advancement of a number of techniques, because the challenges that face proteomics technologies are far reaching. USE OF PROTEOMICS to spot BIOMARKERS Goal of biomarker discovery Biomarkers are biological parameters which will be measured and quantified as indicators for normal health and physiology-related assessments, such as pathogenic processes, environmental exposure, or pharmacologic responses to a drug. Proteomes represent internet results of interactions between genetic background and environmental factors and should be considered because the signature of a disease, involving small circulating proteins or peptides from degraded molecules in various disease state. Proteomics can identify alterations in post-translational modifications, cellular trafficking, and even total expression levels that may not be detected by RNA-based expression studies . Both two-dimensional gel electrophoresis and Mass Spectrometry play a major role in proteomics; however, they are not the only technologies available and necessary.