Neuroscience and Psychiatry: Open Access

Neuroinflammation Journals

The definition of neuroinflammation is an inflammatory response within the brain or spinal cord. This inflammation is mediated by cytokine production, chemokine production, reactive oxygen species and secondary messengers. Resident CNS glia, endothelial cells, and peripherally derived immune cells make these mediators. These neuroinflammatory responses have immune, physiological, biochemical, and psychological consequences. The degree of neuroinflammation also depends on the context, duration, and course of the primary stimulus or offense. For example, inflammation can lead to immune cell recruitment, edema, tissue damage and potentially cell death. However, the term neuroinflammation isn't universally equivalent. Hence, the primary objective here is to discuss different degrees of neuroinflammation and describe pathways in the context of the insult that represent positive and negative aspects of the neuroinflammatory processes.

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