Neuroscience and Psychiatry: Open Access

Neurotoxicity Impact Factor

 The term neurotoxicity refers to break to the brain or peripheral system nervous caused by exposure to natural or semisynthetic nephrotoxic substances. These toxins will alter the activity of the system nervosas in ways in which will disrupt or kill nerves. Nerves area unit essential for sending and process info within the brain, additionally as different areas of the systema nervosas. thanks to their high rate , neurons area unit at the simplest risk of injury caused by neurotoxins. this can be followed, so as of risk, by oligodendrocytes, astrocytes, glia and capillary epithelial tissue cells. betting on a neurotoxin’s chemical profile, it will cause harm to sure components or specific cellular components of the systema nervosum. Non-polar substances area unit a lot of soluble in lipids and might so access the animal tissue a lot of simply than polar compounds, that area unit less soluble in lipids. The body’s response to neurotoxins is influenced by factors just like the neurochemical affected, cellular membrane integrity and so the presence of detoxifying mechanisms.The presence of neurocognitive deficits alone isn't typically thought-about enough proof of neurotoxicity, as several substances could impair neurocognitive performance while not leading to the death of neurons.This might flow from to the dissent of the substance, with the impairment and neurocognitive deficits being temporary, and breakdown once the substance is eliminated from the body. In some cases the extent or exposure-time is also important, with some substances solely changing into toxin in sure doses or time periods. a number of the foremost common present brain toxins that result in neurotoxicity as a results of excessive drug use area unit beta amyloid (Aβ), glutamate, dopamine, and O radicals. once gift in high concentrations, they'll result in neurotoxicity and death (apoptosis). a number of the symptoms that result from necrobiosis embrace loss of control, psychological feature deterioration and involuntary system nervous pathology. in addition, neurotoxicity has been found to be a significant reason behind neurodegenerative diseases like Alzheimer's disease  

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