ISSN: 1755-5191

Imaging in Medicine

D-cell Hypothesis

A new theory, D-cell hypothesis,for understanding mesolimbic DA hyperactivity in pathogenesis of schizophrenia . In brains of patients with schizophrenia, dysfunction of neural stem cells in the subventricular zone of lateral ventricle causes the decrease of D-neurons in the striatum and nucleus accumbens. This contributes to a reduction in trace amine concentrations in the nuclei but conclusive proof has not yet been seen. Enlargement of the lateral ventricle, a common finding documented in schizophrenia brain imaging studies, is possibly due to dysfunction of the subventricular neural stem cells. Metabolisms of TAAR1ligands, and neuropsychiatric disease NSC- and D-neuron-pathophysiology remain to be explored to further improve novel therapeutic strategies. 

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