Advanced Materials Science Research

Biodegradation

Biodegradation of biomaterials introduces more complexities and challenges in the host when compared to non-degradable biomaterials. Until the biomaterial is fully degraded and the implant area remodelled, the host has to respond to the challenges of a changing environment, brought about by the alteration in size, shape and surface topography of the degrading biomaterial. There is also the constant release of degradation products that require timely elimination. The Biomaterial which is resulted are the particles which are degraded polymers which represent additional stimuli for host response. While these issues may produce needless difficulties for the intended application, degradable biomaterials have numerous advantages and eliminate the problem of chronic irritation to the host, as well as the potential for tissue remodelling and regeneration. Hence, biodegradable materials have gained wide recognition and hold promise for several biomedical and tissue engineering applications as temporary scaffolds for tissue replacement, or as delivery vehicles for cells, drugs, bioactive molecules or genes.  Biodegradation is that the transformation of a substance into new compounds through biochemical reactions or the actions of microorganisms like bacteria or, alternatively, bio degradation is that the process by which transform or alter (through metabolic or enzymatic action) the structure of chemicals introduced are altered by microbes  into the 

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