Androgen Receptor
The
androgen receptor, also referred to as NR3C4 may be a sort of nuclear receptor which is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone within the cytoplasm and then translocating into the nucleus. The main function is to regulate
gene expression. Inhibition of
androgen receptor leads to normal and malignant prostate tissue. Developing resistance can be seen after certain period i,e androgen-insensitive prostate
cancer also known as hormone-refractory prostate
cancer or castrate resistant prostate cancer(CRPC). The
androgen receptor (AR), also referred to as NR3C4 (nuclear receptor subfamily 3, group C, member 4), may be a sort of nuclear receptor that's activated by binding any of the androgenic hormones, including
testosterone and dihydrotestosterone within the cytoplasm then translocating into the nucleus. The
androgen receptor is most closely associated with the progesterone receptor, and progestins in higher dosages can block the
androgen receptor. The main function of the
androgen receptor is as a DNA-binding transcription factor that regulates
gene expression; however, the
androgen receptor has other functions also. Androgen-regulated genes are critical for the event and maintenance of the male sexual phenotype. The
androgen receptor (AR) exists in normal liver also as in human hepatoma (HCC) tissues. Recent studies revealed that AR plays a crucial role in
hepatitis B viral also as
hepatitis C viral hepatocarcinogenesis. The targeting of AR could be developed as a replacement therapeutic option against HCC. This article provides
information regarding the association between AR and HCC.
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