Ventricular Hypertrophy Impact Factor
Ventricular hypertrophy (VH) is thickening of the walls of a ventricle (lower chamber) of the guts . [better source needed] Although left ventricular hypertrophy (LVH) is more common, right ventricular hypertrophy (RVH), also as concurrent hypertrophy of both ventricles also can occur. Ventricular hypertrophy may result from a spread of conditions, both adaptive and maladaptive. For example, it occurs in what's considered a physiologic, adaptive process in pregnancy in response to increased blood volume; but also can occur as a consequence of ventricular remodeling following a heart attack. Importantly, pathologic and physiologic remodeling engage different cellular pathways within the heart and end in different gross cardiac phenotypes. The ventricles are the chambers within the heart liable for pumping blood either to the lungs (right ventricle) or to the remainder of the body (left ventricle). Ventricular hypertrophy could also be divided into two categories: concentric (maladaptive) hypertrophy and eccentric (adaptive) hypertrophy. Concentric hypertrophy results from various stressors to the guts including hypertension, congenital
heart defects (such as Tetralogy of Fallot), valvular defects (aortic coarction or stenosis), and first defects of the myocardium which directly cause hypertrophy (hypertrophic cardiomyopathy). The underlying commonality in these disease states is an increase in pressures that the ventricles experience. For example, in tetralogy of Fallot, the right ventricle is exposed to the high pressures of the left heart due to a defect in the septum; as a result the right ventricle undergoes hypertrophy to catch up on these increased pressures. Similarly, in systemic hypertension, the ventricle must work harder to beat the upper pressures of the system and responds by thickening to affect increased wall stress.
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