Journal of Pediatric Neurological Disorders

Type 2 Diabetes (T2D) And Neurodegenerative Diseases

Alzheimer’s disease (AD) and sort 2 diabetes (T2D) present a big risk to every other. Advertisement and T2D are described by statement of cerebral amyloid-β (Aβ) and pancreatic human islet amyloid polypeptide (hIAPP), individually.We investigated the role of amyloidogenic proteins within the interplay between these diseases. A novel double transgenic mouse model combining T2D and AD was generated and characterized. AD-related amyloid transgenic mice coexpressing hIAPP displayed peripheral insulin resistance, hyperglycemia, and glucose intolerance. Aβ and IAPP amyloid co-deposition increased tau phosphorylation, and a discount in pancreatic β-cell mass was detected in islets. Increased brain Aβ deposition and tau phosphorylation and reduced insulin levels and signaling were accompanied by extensive synaptic loss and decreased neuronal counts. Aβ immunization rescued the peripheral insulin resistance and hyperglycemia, suggesting a task for Aβ in T2D pathogenesis for people predisposed to AD. These findings demonstrate that Aβ and IAPP are key factors in the overlapping pathologies of AD and T2D.—Wijesekara, N., Ahrens, R., Sabale, M., Wu, L., Ha, K., Verdile, G., Fraser, P. E. Amyloid-β and islet amyloid pathologies link Alzheimer’s disease and sort 2 diabetes during a transgenic model. A growing body of evidence links type-2 diabetes (T2D) with dementia and neurodegenerative diseases like Alzheimer's disease (AD). AD is that the commonest sort of dementia and is characterised neuropathologically by the buildup of extracellular beta amyloid (Aβ) peptide aggregates and intracellular hyper-phosphorylated tau protein, which are thought to drive and/or accelerate inflammatory and oxidative stress processes resulting in neurodegeneration. Although the precise mechanism remains unclear, T2D can exacerbate these neurodegenerative processes.    

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