Secretomics
Secretomics may be a sort of proteomics which involves the analysis of the secretome—all the secreted proteins of a cell, tissue or organism. Secreted proteins are involved during a sort of physiological processes, including
cell signaling and matrix remodeling, but also are integral to invasion and metastasis of malignant cells.
Secretomics has thus been especially important within the discovery of
biomarkers for
cancer and understanding molecular basis of pathogenesis.The analysis of the insoluble fraction of the secretome has been termed matrisomics. HISTORY OF SECRETOMICS -In 2000 Tjalsma et al. Coined term secretome in their study of the eubacterium B subtilis. They defined the secretome as all of the secreted proteins and secretory machinery of the bacteria. employing a database of protein sequences in B. subtilis and an algorithm that checked out cleavage sites and amino-terminal signal
peptides characteristic of secreted proteins they were ready to predict what fraction of the proteome is secreted by the cell. In 2001 an equivalent lab set a typical of
secretomics – predictions supported aminoalkanoic acid sequence alone aren't enough to define the secretome. They used two-dimensional gel
electrophoresis and
mass spectrometry to spot 82 proteins secreted by B. subtilis, only 48 of which had been predicted using the genome-based method of their previous paper. This demonstrates the necessity for protein verification of predicted findings.
High Impact List of Articles
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Intraoperative fluorescence-imaging of nerves - a contribution to navigation surgery
Akio Sugitachi*, Koki Otsuka, Fumitaka Endo, Toshimoto Kimura, Takeshi Takahara, Yuji Akiyama, Takeshi Iwaya, Hiroyuki Nitta, Keisuke Koeda, Masaru Mizuno & Akira Sasaki
Research Paper: Imaging in Medicine
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Intraoperative fluorescence-imaging of nerves - a contribution to navigation surgery
Akio Sugitachi*, Koki Otsuka, Fumitaka Endo, Toshimoto Kimura, Takeshi Takahara, Yuji Akiyama, Takeshi Iwaya, Hiroyuki Nitta, Keisuke Koeda, Masaru Mizuno & Akira Sasaki
Research Paper: Imaging in Medicine
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Perflutren lipid microsphere injectable suspension for cardiac ultrasound
Sahar S Abdelmoneim and Sharon L Mulvagh
Contrast Agent Evaluation: Imaging in Medicine
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Perflutren lipid microsphere injectable suspension for cardiac ultrasound
Sahar S Abdelmoneim and Sharon L Mulvagh
Contrast Agent Evaluation: Imaging in Medicine
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Overview on the efficacy and safety of gadobutrol: an MRI contrast agent for the CNS, body and vessels
Juan E Gutierrez, Sara Koenig and Josy Breuer
Contrast Agent Evaluation: Imaging in Medicine
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Overview on the efficacy and safety of gadobutrol: an MRI contrast agent for the CNS, body and vessels
Juan E Gutierrez, Sara Koenig and Josy Breuer
Contrast Agent Evaluation: Imaging in Medicine
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Improving high-field MRI using parallel excitation
William A Grissom, Laura Sacolick and Mika W Vogel
Review Article: Imaging in Medicine
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Improving high-field MRI using parallel excitation
William A Grissom, Laura Sacolick and Mika W Vogel
Review Article: Imaging in Medicine
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Delayed-enhancement cardiac MRI in the evaluation of cardiomyopathies
Thananya Boonyasiranant and Scott D Flamm
Review Article: Imaging in Medicine
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Delayed-enhancement cardiac MRI in the evaluation of cardiomyopathies
Thananya Boonyasiranant and Scott D Flamm
Review Article: Imaging in Medicine
Relevant Topics in General Science