Scientific Journals On Ichthyosis Vulgaris
Harlequin ichthyosis is a rare form of ichthyosis that is present at birth. A newborn with the condition will have thick plates of skin that crack and split apart. Eating and breathing may be difficult, and
infection may occur.
In the past, it was difficult to survive more than a few days with this condition. Now, however, treatment is available. If applied immediately, it can be effective. Some children with harlequin ichthyosis are already living into their teens and 20s.
Causes
Most cases of ichthyosis vulgaris are caused by a mutation in the
gene responsible for encoding filaggrin. This is a protein that helps create the skin’s natural barrier.
Without an effective barrier, the skin struggles to retain moisture and a consistent pH.
Chronically dehydrated skin
cells begin to thicken and harden as they age. They then move to the surface of the skin, where they become fixed scales.
A vast majority of ichthyosis cases are inherited. Individuals with one copy of the abnormal
gene tend to have milder cases than those with two copies.
The condition can also be caused by:
· the use of certain medications
· systemic conditions
· conditions that affect the entire body
· Common causes of acquired ichthyosis include:
· impaired thyroid function
· Hodgkin lymphoma
· HIV
· sarcoidosis
· organ failure, especially liver and kidney failure
· many medications targeted
cancer therapy drugs
· medicines containing nicotinic acid
· medications containing kava
· hydroxyurea
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