Annals of Clinical Trials and Vaccines Research

Scholarly Open Access Journals In Immunhistochemistry

 Immunohistochemistry (IHC) is that the commonest application of immunostaining. IHC takes its name from the roots "immuno", in regard to antibodies utilized in the procedure, and "histo", meaning tissue (compare to immunocytochemistry). Albert Coons conceptualized and first implemented the procedure in 1941.   Visualising an antibody-antigen interaction can be accomplished in a number of ways, mainly either of the following: Immunofluorescence, where the antibody is tagged to a fluorophore, like fluorescein or rhodamine. Immunohistochemical staining is widely utilized in the diagnosis of abnormal cells like those found in cancerous tumors. Specific molecular markers are characteristic of particular cellular events like proliferation or necrobiosis (apoptosis). Immunohistochemistry is additionally widely utilized in basic research to know the distribution and localization of biomarkers and differentially expressed proteins in several parts of a biological tissue.    

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