JBR Journal of Interdisciplinary Medicine and Dental Sciences

Osteosarcoma-Scholarly Journal

Cancerous tumor in a bone is an osteosarcoma (OS) or osteogenic sarcoma (OGS) (or simply bone cancer). Specifically, it is an aggressive malignant neoplasm that originates from mesenchymal primitive transformed cells and exhibits osteoblastic differentiation and produces malignant osteoid. Teenagers who are active in sports often complain about pain in the lower femur, or right under the knee. If the tumor is large, localized swelling may occur as overt. Sometimes the first symptom is a sudden fracture, because the affected bone is not as strong as the normal bone and may fracture abnormally with minor traumas. Osteosarcomas tend to occur at bone growth sites, presumably because proliferation in this region makes osteoblastic cells prone to acquiring mutations that can lead to cell transformation. Because of this tendency, some large dog breeds show high incidence of osteosarcoma. At the end of the long bone the tumor may be localized. It most often affects the proximal tibia or humerus end, or the distal femur end.    

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