Neuroscience and Psychiatry: Open Access

Neuroimmunology Open Access Articles

 Despite having a well-controlled immune system, brain cells are vulnerable to damages caused by autoimmune diseases, including multiple sclerosis. In the case of an autoimmune disease, the immune system starts attacking the body’s own cells and proteins by recognizing them as foreign particles. As a result, a cascade of detrimental damages takes place, which can be fatal, especially if such attacks occur inside the brain. Apart from playing an active role in diseased conditions, the immune system actively participates in natural development and maintenance of the brain. As the brain develops, many new neuronal connections are made and old connections are lost. Microglia maintain the brain homeostasis by removing old connections and ensuring proper functioning of new connections. In addition, the immune system is also actively involved in the formation of new neurons.  

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