ISSN: 1755-5191

Imaging in Medicine

Immobilization Of Biomolecules

Immobilizing biomolecules includes three major methods: physical adsorption, physical “entrapment” and covalent attachment. The Physical adsorption plays a prominent role in immobilization of biomolecules because the primary step to immobilise the protein is always the adsorption process. The activity and stability of a molecule can be adversely affected due to uncontrolled adsorption at surface. The physical adsorption includes the electrostatic interactions and entrapment includes hydrogels. The covalent attachment involves the chemical attachment to the support molecules. It is important to be noted that the word “immobilization” can refer to a short-term, long-term or “permanent” localization of the biomolecule as it involve the pair of molecules with strong affinity interactions.    

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