ISSN: 1939-067X

Journal of Experimental Stroke & Translational Medicine

Enolase1

Enolase one (ENO1), additional ordinarily called alpha-enolase, could be a glycolytic protein expressed in most tissues, one amongst the isozymes of enolase. Every isoenzyme could be a homodimer composed of two alpha, 2 gamma, or two beta subunits, and functions as a glycolytic protein. Alpha-enolase, additionally, functions as a structural lens macromolecule (tau-crystallin) within the monomeric kind. Different junction of this cistron leads to a shorter isoform that has been shown to bind to the c-myc promoter and performance as a neoplasm suppressor. Many pseudogenes are known, as well as one on the long arm of body one. Alpha-enolase has conjointly been known as associate degree autoantigen in Hashimoto neurological disorder. As AN enolase, ENO1 could be a glycolytic catalyst the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate.This isozyme is ubiquitously expressed in adult human tissues, as well as liver, brain, kidney, and spleen. among cells, ENO1 preponderantly localizes to the protoplasm, although AN as an alternative translated type is localized to the nucleus.[6][9] Its nuclear type, additionally called MBP1, functions only as a growth suppressor by binding and inhibiting the c-myc protooncogene promoter, and lacks the glycolytic catalyst activity of the protoplasm type.[10] ENO1 additionally plays a job in different functions, as well as a cell surface receptor for fibrinolysin on pathogens, like streptococci, and activated immune cells, resulting in general infection or tissue invasion; AN aerophilic stress macromolecule in epithelial tissue cells; a lens crystalline; a heat shock protein; and a binding partner of cytoskeletal and chromatin granule structures to assist in transcription

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