Annals of Clinical Trials and Vaccines Research

Dementia Pathophysiology

 The degenerative diseases are characterized clinically by loss of neurological function (dementia, loss of movement control, paralysis), and pathologically by loss of neurons. In a number of them, loss of neurons is amid specific histopathological findings like Alzheimer's plaques and Lewy bodies. Others show gradual neuronal atrophy and loss, without specific pathology. Some degenerative diseases involve specific anatomical systems or interconnected sets of neurons. The pathology is either diffuse or, when it's focal, is bilateral and symmetric. Degenerative diseases are inexorably progressive. Most of them are diseases of adulthood , but some involve children , including children. The term "degenerative" or "neurodegenerative," is vague. it's now becoming clear that degenerative diseases have a biochemical basis. Many degenerative diseases are inherited. Their genes are known and DNA-based diagnosis (including prenatal diagnosis) is out there in many of them. More information about the gene products and understanding of pathophysiological mechanisms will open the thanks to specific treatments. the foremost common condition is Alzheimer's disease and therefore the second most frequent is paralysis agitans .Central to the pathology and pathogenesis of degenerative diseases is that the deposition of abnormal proteins within the brain. In some diseases, normally soluble proteins misfold into a beta-pleated pattern and alter into insoluble fibrillary amyloid. These deposits are often identified in tissue sections, frequently sure to ubiquitin, and are specific surely groups of disorders. The table below lists the main proteinopathies.  

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