Bioprocesses have cleaved as a significant means to support fulfill and survival divergent needs for thousands of years in the human history. Prior bioprocesses engaged natural microorganisms, such as fungi and yeasts, to produce different products, including beer, bread, and cheese. The first purification step was ethanol distillation transferred out around 2000 BC. With advances in engineering and science, bioprocess improves in both complexity and production scale with integrated processing ways. In addition to nature microorganisms, contemporary bioprocesses also use other agents, e.g. cells and enzymes from insects, plants, and animals, to produce various products, including antibiotics, organic acid, and therapeutic compounds. Bioprocesses are evolved by combining different basic steps, such as filtration, fermentation and drying. For decades, scaling up from a system via a pilot plant to a full-blown factory has been the standard practice of the evolution of industrial-scale bioprocesses.  

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