Review Article - Imaging in Medicine (2013) Volume 5, Issue 4

Unenhanced CT in the evaluation of renal/ureteric colic

Tze M Wah*

Diagnostic & Interventional Radiology, Leeds Teaching Hospitals Trust, St James’s University Hospital, Beckett Street, Leeds, LS9 7TF, UK

Corresponding Author:
Tze M Wah
Diagnostic & Interventional Radiology
Leeds Teaching Hospitals Trust
St James’s University Hospital
Beckett Street, Leeds, LS9 7TF, UK
Tel: +44 113 206 5525
Fax: +44 113 206 4640
E-mail: [email protected]

Keywords

CTKUB ▪ renal colic ▪ stone ▪ unenhanced CT

Acute loin pain due a to renal or ureteric stone is a common diagnosis in the accident and emergency department [13]. A stone in the kidney alone does not warrant emergency management apart from in the context of superimposed infection, but a stone impacted within the ureter requires prompt diagnosis, urological referral and urgent intervention in specific circumstances. The classical clinical symptoms of ureteric colic, such as loin pain that radiates to the groin, vomiting and microscopic hematuria, frequently overlaps with other clinical presentations such as pyelonephritis, appendicitis, gynecological problems or diverticulitis. Therefore, imaging plays an important role in obtaining an accurate diagnosis with this clinical presentation so that the patient can be promptly triaged into the correct clinical management pathway. The majority (70%) of the stones detected are calcium oxalate and/or phosphate composition, 8% are uric acid stones and 3% cysteine stones [4]. They can present as a small stone or a staghorn calculus that fills multiple collecting systems. The treatment for a urinary tract stone may range from extracorporeal shock wave lithotripsy, retrograde ureteroscopy with laser fragmentation to percutaneous nephrolithotomy.

Intravenous urography (IVU) has been used since 1923 to investigate the symptoms of acute loin pain. Since the arrival of CT, this has revolutionized the way clinicans image urinary tract disease. Today, noncontrast enhanced CT of kidneys, ureters and the bladder (CTKUB) has replaced acute IVU and transformed the imaging approach for patients with acute loin pain presenting to the emergency department. The diagnostic utility of CTKUB was first described by Smith et al. in 1995 and has shown better detection of ureteric stones in terms of diagnostic accuracy, sensitivity and specificity when compared with IVU [5]. This was confirmed subsequently by other published series for CTKUB versus IVU with sensitivities of 94–100 versus 66–87% and specificities of 94–100 versus 92–94%, respectively [69]. CTKUB assessment can provide information about the size, density and distribution of stones in the kidney/site of stone impaction in the ureter [1012] and secondary signs of obstruction such as perinephric stranding, hydronephrosis and hydroureter [1315]. In addition, CTKUB also detects extraurinary abnormalities that may clinically mimic acute renal or ureteric colic [1012,16].

However, there are a few potential imaging pitfalls that radiologists may encounter during CTKUB interpretation. These are other tubular structures, such as gonadal vessels or phleboliths, in the pelvis and when there is presence of a ureteral stent this can obscure the presence of a stone adjacent to it. Therefore, understanding the anatomical relationships of the ureter is crucial in assisting diagnosis. Multiplanar reformatting, such as coronal reformatting, may also clarify the location of the stone and using wide windowing during interpretation may differentiate a small stone adjacent to the ureteral stent.

Detection of the stone either in the kidney or ureter in the emergency setting is important so that patients can be referred for timely clinical management but the follow-up imaging strategy is equally important especially for patients who are treated with conservatively – that is, waiting for the stone to pass spontaneously. To date, there remain many divergent approaches as to following- up these patients. Some stones may not be visualized on plain radiography and potentially CT scout views may be used to guide whether subsequent follow-up with plain radiograph is possible depending on its visibility on initial scout view on the CTKUB [17]. Accurate imaging diagnosis is vital in order to prevent a patient having to undergo unnecessary endourological intervention.

This paper aims to describe the normal anatomy of the kidney and ureter; illustrate the salient signs on CTKUB for urinary tract stones causing renal or ureteric colic; outline the potential imaging pitfalls; and discuss the possible role of CT scout views as well as exploring Randall’s plaque theory.

Normal anatomy

The ureter is a muscular tubular structure that measures 25 cm in length and drains via peristalsis. It is typically subdivided into: proximal (including the renal pelvis), middle, distal and the vesico–ureteric junction (VUJ) [18]. The ureter passes inferomedially from the renal hilum (Figure 1), where the renal pelvis lies behind the main renal vein and artery. The proximal two-thirds (proximal and middle) of the ureter crosses within the abdomen, and lies anterior to the psoas muscle, which separates the ureter from the underlying tips of the transverse processes of the lumbar vertebral bodies from L2 to L5. It is important to note that the gonadal vessel crosses anteriorly to the ureter in the middle third (Figure 2).

imaging-in-medicine-ureter

Figure 1: Anatomy of ureter in relation to other structures. The ureter passes inferomedially from the renal hilum where the renal pelvis lies behind the main renal vein and artery.
CIA: Common iliac artery; EIA: External iliac artery; IIA: Internal iliac artery.

imaging-in-medicine-gonadal-vessel

Figure 2: CT demonstrating that the gonadal vessel (long arrow) crosses anteriorly to the ureter (short arrow) in the middle third.

The abdominal ureter becomes the distal or pelvic ureter as it passes over the pelvic brim. The distal pelvic ureter runs over the lateral wall of the pelvis, crosses anterior to the common iliac artery and then posterior to the superior vesical branch of the internal iliac artery. In the male pelvis, the distal ureter then passes anteromedially behind the vas deferens (Figure 3) before the ureter passes to the bladder base. In the female pelvis, the ureter runs through the stiff band of fibrous tissue (the ligament of Mackendrodt) on either side of the cervix as it approaches the bladder (Figure 4). At the VUJ, the intravesical portion of the ureter passes obliquely through the muscular wall to help produce a valve-like arrangement to prevent urinary reflux [18].

imaging-in-medicine-bladder-base

Figure 3: Male pelvis showing that the distal ureter passes anteromedially behind the vas deferens before the ureter passes to the bladder base.
CIA: Common iliac artery; EIA: External iliac artery; IIA: Internal iliac artery.

imaging-in-medicine-female-pelvis

Figure 4: Relatinship of the ureter in the female pelvis. In the female pelvis, the ureter runs through the stiff band of fibrous tissue (the ligament of Mackendrodt) on either side of the cervix as it approaches the bladder. CIA: Common iliac artery; EIA: External iliac artery; IIA: Internal iliac artery.

There are three recognized locations where stones may be impacted due to normal anatomical narrowing of the ureter: the pelvi–ureteric junction; at the level ureter crosses the pelvic brim; and the VUJ.

It is pertinent to be aware of the normal anatomical variants of the collecting system that can also predispose to stone formation. Duplex kidney is the most common congenital normal variant of the urinary tract that may remain concealed in the absence of associated complications [19]. However, it frequently occurs in association with other urinary tract anomalies such as ureterocele causing upper moiety obstruction, or a defective VUJ valve mechanism causing urinary reflux to the lower moiety [20]. Both situations may present on imaging with a dilated collecting system of the associated moiety [21].

CTKUB technique

Today, multidetector CTs allow volume acquisition of information, and real-time reformatting in both the sagittal and coronal sections. CTKUB is now the ‘gold standard’ for the diagnosis of ureteric stones in the context of acute loin pain [2]. This technique is suitable for acute assessment as it requires no patient preparation and no oral or intravenous contrast is needed. Prone position scanning is preferred as this allows stones that have been passed into the bladder to be differentiated from stones that are impacted at the VUJ (Figure 5) [22]. Patients are scanned from the kidneys to the bladder base. With the CTKUB assessment, the female pelvis usually receives direct radiation exposure, and the authors have also found in their practice that female patients had a significantly lower positive rate than male patients (26.8 vs 61.6%) [3,23]. Further investigation into the young female patients in the cohort with ureteric calculus >4 mm has shown that hydronephrosis was present in 83% of cases [3]. Therefore, indiscriminate use of CTKUB in young female patients is unadvisable and a screening ultrasound scan should be used as a first-line investigation to identify the gynecological pathology and to detect the presence of hydronephrosis before performing CTKUB [3].

imaging-in-medicine-kidneys

Figure 5: Prone CT of the kidneys, ureters and bladder shows that the nondependent stone is impacted at the vesico–ureteric junction (arrow).

The CTKUB technique is a dedicated protocol to assess for urinary tract stones and is less sensitive in detecting the other intra-abdominal/pelvic pathology. However, significant extraurinary pathology may be detected on CTKUB in 9–29% of the cases [2,3,24]. If clinically indicated, this may be further assessed with administration of contrast agents.

The only drawback of CTKUB is the relatively high radiation exposure, with typical doses in the range of 4.7–6.5 mSv (and greater for multidetector CT) compared with 1.5– 3.3 mSv for an IVU series [6,2527]. The estimated risk of lifetime induction of fatal cancer is one in 4000, one in 43,000 and one in 130,000 for a CTKUB, three-film IVU series and plain kidneys, ureters and bladder (KUB) film, respectively [2729].

In the quest of reducing the radiation dose and maintaining the diagnostic quality of the CTKUB, a low-dose technique has been developed and is currently widely adopted [2832]. The low-dose CTKUB technique provides comparable diagnostic accuracy with sensitivity of 97% and specificity of 95% by increasing beam width and pitch and reducing exposure factors. This can reduce the dose to as little as 0.5 mSv for men and 0.7 mSv for women [3337]. The only pitfalls that one needs to be aware of stones <3 mm, stones impacted at VUJ or stones in obese patients may not be detected with the low-dose technique [28,31,3335].

The attenuation of the various types of stones overlap greatly with the conventional single energy CT; hence, stone composition cannot be differentiated. However, the dual energy CT appears to have the ability to characterize stone composition, as their attenuation values differ significantly when scanned with high- and low-energy CT [38]. Dual-energy CTKUB has the potential benefit of differentiating low molecular weight stones, such as uric acid stones, from high molecular weight stones, such as calcium oxalate, or cysteine stones, which typically have higher attenuation values at lower-energy CT. The characteristic difference in attenuation values with dual energy CT scanning at 80 and 120–140 kV potentially allows the determination of stone composition [39]. This can stratify stone management where uric acid stones may benefit from medical management and consideration of percutaneous nephrolithotomy surgery for harder stones such as cysteine and certain calcium stones, which may be more resistant to extracorporeal shock wave lithotripsy. Recent literature suggests that dual-energy CT can accurately differentiate the stone composition, but there is limitation when the stone is less than 1 cm [4043]. In addition, this technique is also associated with higher radiation doses and work is currently being carried out to reduce the radiation dose [43]. Targeted dual-energy CT for a stone detected on the conventional CTKUB has been explored [44].

Image review at Picture Archiving & Communication System workstation

Image review is best performed at a Picture Archiving and Communication System (PACS) workstation. Multiplanar reformatting, especially the coronal reformat, simulates the conventional plain radiograph orientation and has been found to be most helpful in the majority of cases during interpretation [35]. Accurate stone size estimation with measurement of the maximal width can be performed using the electronic calliper, and maximal stone width is the most important predictor of spontaneous stone passage [45]. Both stone size and location are important radiological factors that influence the management strategy that varies from conservative management with simple analgesia to invasive endourological procedures [46,47].

Most CTKUB studies dating back to the 1990s were interpreted with hard-copy films on a viewing box [29,37,48,49]. The current practice uses softcopy reviewing at PACS workstations to interpret these images, where the reviewer can trace the ureter from the kidney to the bladder in a continuous sweep of observation rather than a discontinuous observation with having to flick from image to image with the hard-copy film review [29,33,34,36,50]. For image review at a PACS workstation, each ureter is reviewed in turn, and then the remainder of the abdomen and pelvis is assessed, as well as the bones, on suitable soft tissue and bone window settings.

Radiology findings

The primary sign of renal or ureteric colic on CTKUB is the identification of a high attenuation focus within the kidney or lumen of a ureter (Figures 5 & 6). Images are reviewed with soft tissue window settings on PACS. All stones are visible on CT (Hounsfield units [HU] = 200–600) apart from indinavir crystals, where regardless of the particular stone composition it will be detected against the soft tissue density of the ureteral wall [51]. Identification of a stone within the kidney or ureter on the symptomatic side gives a positive diagnosis of renal or ureteric colic.

imaging-in-medicine-CT

Figure 6: Selective axial CT of the kidneys, ureters and bladder shows a stone in the lower pole calyx (short arrow) of the left kidney and another stone impacted at the proximal left ureter (long arrow).

Challenges arise during interpretation when there are extraurinar calcifications, tubular structures close to the course of the ureter or the presence of a ureteral stent. Extraurinary calcifications such as phleboliths (Figure 7) – that is, foci of calcification within the walls of veins – can mimic ureteric stones. Tubular structures that course in close anatomical relation to the ureter, such as gonadal, perivesical, periprostatic and perivaginal veins, can result in a falsepositive diagnosis (Figure 2) [14]. The diagnostic confidence is worsened when there is paucity of intra-abdominal fat, and in some patients the ureter is difficult to trace from the outset. It is important to be aware that the presence of ureteral stents can obscure adjacent small ureteric stones and wide windowing such as bone window settings may be helpful in detecting this (Figure 8).

imaging-in-medicine-phlebolith

Figure 7: CT of the kidneys, ureters and bladder shows a phlebolith (arrow) in the left pelvic side wall.

imaging-in-medicine-tissue-window

Figure 8: Soft tissue window on a CT of the kidneys, ureters and bladder. Demonstrates a clump of dense calcification (A) in the left mid-ureter and (B) on the bony window, where the presence of a small stone (short arrow) anterior to the ureteral stent (long arrow) is more prominent.

Systematic review of the CTKUB on a PACS workstation is important to detect the cause of patient’s symptoms. The observations should include primary signs of stones (Figure 9), secondary signs of stones, renal calcification that would necessitate long-term urological follow-up such as medullary sponge kidney (Figure 10), complications related to stone treatment (Figure 11), measurement of the predictor of stone free rate for extracorporeal shock wave lithotripsy, such as HU and skin to stone distance on CT [52,53] and search for alternative diagnoses to stones such as acute appendicitis, gallstones and gynecological abnormalities.

imaging-in-medicine-right-proximal

Figure 9: Coronal CT of the kidneys, ureters and bladder shows a right proximal ureteric stone (arrow).

imaging-in-medicine-medullary-sponge

Figure 10: CT of the kidneys, ureters and bladder shows classic medullary sponge kidney appearance with bilateral and asymmetrical medullary calcifications in the pyramids.

imaging-in-medicine-ureters-bladder

Figure 11: CT of the kidneys, ureters and bladder. Demonstrates (A) a left upper ureteric stone (long arrow) and (B) a large fluid collection around the ureter postureteroscopy due to iatrogenic injury (short arrow). A ureteral stent (horizontal arrow) is sited to allow healing of the ureter.

The following section will illustrate a few well-described imaging signs on CTKUB that can assist with the diagnosis of ureteric obstruction when the reader encounters an indeterminate calcific focus. These can either be direct signs that are directly associated with calcification or indirect secondary signs that are due to the effect of ureteric obstruction.

Direct sign: soft tissue rim sign

The soft tissue ‘rim’ sign describes the edematous rim of the ureteral wall surrounding the impacted stone within the lumen of the ureter. It is typically defined as a 1–2 mm rim of soft tissue measuring 20–40 HU that surrounds the impacted stone in the ureter (Figure 12) [5,54].

imaging-in-medicine-soft-tissue

Figure 12: The classic soft tissue ‘rim’ sign on a CT of the kidneys, ureters and bladder (arrow).

The soft tissue rim sign usually disappears when the stone is >6 mm and this is usually due to the stone stretching the wall of the ureter, thus limiting the visibility of the edema (Figure 13) [54,55].

imaging-in-medicine-large-stone

Figure 13: A large stone (>6mm; arrow) impacted at the right upper ureter, and the soft tissue rim sign is absent.

Another difficult area for interpretation is a stone at the VUJ. This is largely due to the fact the ureter has a horizontal course (Figure 14), there is very little intrapelvic fat to contrast with the rim as well as the abundant muscular wall of the intravesical portion (Figure 5). Therefore, this sign is unreliable at the VUJ [14,15,54,55]. The estimated sensitivity and specificity of the soft tissue rim sign (excluding VUJ stones) are 77 and 92%, respectively, in differentiating stones from phleboliths [55]. The positive predictive value of the soft tissue rim sign for identifying a ureteric calculus has been estimated at 84–100%, but VUJ stones (a common site of stone impaction) are excluded [5457].

imaging-in-medicine-horizontal-course

Figure 14: The horizontal course (arrow) of the right distal ureter at the right vesico–ureteric junction.

It is important to note that phleboliths can demonstrate a positive soft tissue rim sign in approximately 9% of cases [14,54,55] and this may be due to visualization of the noncalcified portion of a pelvic vein and CT volume averaging [56].

Direct sign: comet tail sign

The ‘comet tail’ sign describes the adjacent eccentric tapering soft tissue mass corresponding to the noncalcified portion of the pelvic vein associated with a phlebolith (Figures 7 & 15) [48,56,57]. The comet tail sign has 100% specificity and 65% sensitivity for differentiating phleboliths from a stone in the ureter with a positive predictive value of identifying a phleobolith of 100% [48,56].

imaging-in-medicine-comet-tail

Figure 15: CT of the kidneys, ureters and bladder shows a classic comet tail sign in a phlebolith (arrow) at the right pelvic side wall.

Indirect secondary signs

The secondary signs of urinary tract obstruction include nephromegaly, hydronephrosis, hydroureter and perinephric stranding or edema. The sensitivity and specificity are: nephromegaly 71 and 89%, hydronephrosis 69–83 and 94%, hydroureter 67–90 and 93% and perinephric edema 65–82 and 93%, respectively (Figure 16) [14,15]. In addition, the positive predictive value of hydroureter and hydronephrosis in predicting an ipsilateral obstructing stone is 99% [14,15]. The clinical suspicion of the recent passage of a stone through the ureter must be high on the differential diagnosis in patients with hydronephrosis and hydroureter on the symptomatic side in the absence of a visible stone [50].

imaging-in-medicine-coronal-reformat

Figure 16: Axial and coronal reformat CT of the kidneys, ureters and bladder. Demonstrates a small stone (A) impacted at the left upper ureter causing mild left hydronephrosis (arrow) and (B & C) perinephric edema (arrows).

Perinephric fluid stranding on CTKUB (in the presence of stone disease) is due to increased lymphatic flow within the perinephric space and resorbed urine due to obstructive back pressure [58]. The degree of perinephric edema is proportional to the degree of obstruction on excretory urography [49]. The extent of the stranding is also related to the time after onset of pain, which becomes apparent at 2 h and is maximal at 8 h [50]. It also persists for some time after passage of a stone. On its own, perinephric edema is nonspecific, especially in the elderly where this is of no clinical significance. Occasionally, unilateral perinephric edema may be encountered in patients with pyelonephritis or malignancy. In high pressure obstruction, rupture of the fornices may occur, resulting in urine leak from the calyces into the perinephric space.

Sometimes, the ‘pale kidney sign’ may be observed when there is <5 HU in the obstructed renal parenchyma due to edema, resulting in a difference in renal parenchymal attenuation between the obstructed and unobstructed kidneys (Figure 17) [59].

imaging-in-medicine-ureteric-stone

Figure 17: Coronal reformat of a CT of the kidneys, ureters and bladder shows a small left distal ureteric stone (short arrow) obstructing the left kidney and the dominant secondary sign is the pale kidney sign (long arrow) displayed by the left kidney.

Xanthogranulomatous pyelonephritis

Xanthogranulomatous pyelonephritis is a rare chronic destructive granulomatous process of renal parenchyma that occurs with chronic urinary tract obstruction and infection [60]. It affects all age groups and is more common in women. The patients are usually symptomatic with the most common symptoms being loin pain, palpable abdominal mass, lower urinary tract symptoms, weight loss, pyrexia and macroscopic hematuria. The patients usually have raised leucocytes and low hemoglobin with positive urine cultures for Escherichia coli and Proteus mirabilis. CT is the diagnostic imaging of choice for the detection of xanthogranulomatous pyelonephritis [61]. The management options are antibiotics and surgery depending on the patient’s disease status.

Extraurinary pathology

CTKUB may detect alternative symptomatic pathologies in up to 29% of patients with no accepted standard range [2,3,10,25,6264]. The commoner causes include gallstones (Figure 18), acute appendicitis (Figure 19) and ovarian abnormalities (Figure 20). Furthermore, there is also no stated consensus on what is an acceptable positive pick-up rate for ureteric colic, with a reported range of 44–55.7% [25,62,63].

imaging-in-medicine-laminated-gallstone

Figure 18: CT of the kidneys, ureters and bladder shows a large laminated gallstone in the gallbladder.

imaging-in-medicine-bladder-examination

Figure 19: Acute appendicitis (arrow) is detected on the CT of the kidneys, ureters and bladder examination.

imaging-in-medicine-ovarian-cancer

Figure 20: CT of the kidneys, ureters and bladder detected ovarian cancer (arrow) as the cause of the patient’s symptoms.

In fact, it is well recognized that local referral criteria play a crucial role in the positive stone detection rate and can be directly influenced by clinician referral. Indication creep is in fact a scenario where clinicians have broadened the indications for CTKUB after a period of time. This phenomenon has been observed with decreasing positive CTKUB for stones from 49 to 28% and increases in the alternative extraurinary pathology detection from 16 to 45% over a 12-month period [16]. Therefore, it is important to perform a cyclical audit of clinical practice to ensure no indication creep, as shown in the authors’ experience [3], and that clinicians are regularly updated with relevant education meetings and imaging protocols [3,65].

Randall’s plaque theory

The Randall’s plaque theory suggests that a renal stone forms from deposition of calcium phosphate immediately under the renal papillary epithelium, known as Randall’s plaque, which initiates more calcium adherence and results in renal stone formation [66]. Randall’s plaque is frequently observed in calcium oxalate stone formers [67]. Therefore, current exploratory works have suggested that the recurrent stone former has higher density measurement in the papillary region and measurement of the density on the CTKUB in the papillary region could potentially be used to identify the high-risk recurrent stone former, so to warrant longer-term follow-up [68,69].

Imaging follow-up in patients with urinary stone disease

CTKUB is now the first-line investigation for acute loin pain with clinical suspicion of urinary stone disease and pre-CTKUB has now been omitted from the authors’ departmental imaging pathway since 2008, given that 50% of the patients with suspected ureteric colic do not have stone disease [65]. The challenge is for the group of patients with stones in the ureter who have been managed conservatively. Repeated CTKUB examinations would not be an ideal way of following-up these patients owing to cost and radiation burden. As a result of this, interpretation of CT scout radiographs that are routinely performed during CTKUB has been increasingly incorporated into the management algorithm. The sensitivities of the scout view of CTKUB and plain KUB in detecting stones range from 40 to 52 versus 52 to 60%, respectively [17,7073].

It is well documented that the majority of ureteric stones <5 mm will pass spontaneously, especially for distal ureteric stones [74]. Though the sensitivity is not as good for the detection of stones <4 mm with CT scout radiographs, these patients are unlikely to need intervention and hence follow-up imaging. The authors also noted that the sensitivity of stone detection based on location is superior when the stones are located in the upper tract compared with the distal ureter/VUJ. In clinical practice, upper tract stones are more likely to need follow-up, as they are likely to be treated if they are large and have the potential to cause obstruction if they migrate distally. The positive predictive value of a stone visible on the CT scout view is reported to be 100%, in the authors’ experience [17]. Therefore, if stones are visible on CT scout radiographs, then baseline plain KUB is unnecessary. However, if stones are not visible on CT scout radiographs, plain KUB should be performed at the time of the CTKUB. The subsequent follow-up investigation will then depend on the visibility of the stone on plain KUB. If the stone is not visible on plain KUB, then follow-up imaging will need to be either ultrasound, to detect the resolution of hydronephrosis, or potential repeat CTKUB depending on the clinical indication and assessment by the urologists.

Conclusion

CTKUB is the standard investigation for acute renal/ureteric colic in current clinical practice and promptly triaged patients referred from the emergency department. Understanding the normal anatomy for the ureter will assist in the interpretation and awareness of direct and indirect radiological signs and will enhance the differentiation of stones from other conditions. Furthermore, it is important to examine the rest of the CT scan carefully in order to pick up alternative diagnoses that may mimic the nonspecific acute loin pain in this cohort of patients. The follow-up strategy, with both cost and radiation taken into account, is equally important in monitoring the recurrent stone former and also to assess whether the ureteric stone has passed with conservative management in patients with stones detected on initial CTKUB.

Future perspective

Dual-energy CT is a promising technique to be incorporated into clinical practice in the future if further work could be used to facilitate the reduction of the radiation dose associated with the technique. This can assist the differentiation of the different soft and hard stones which can be triaged appropriately for their stone management.

Financial & competing interests disclosure

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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References

    • Ultrasound screening in young females is recommended rather than an indiscriminate use of CT scan of the kidneys, ureters and bladder (CTKUB), following review of a large CTKUB practice at a tertiary referral institution.

    • • Suggests that the composition of stone’s ability can be differentiated with the dual-energy CT.

    • • Current literature demonstrating the limitation of dual-energy CT in determining the stone composition, when stone size is <1 cm.

    • • Paper on the application of dual-energy CT in the urinary tract.

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