Mini Review - International Journal of Clinical Rheumatology (2023) Volume 18, Issue 5

Immunopathology and Types of Hypersensitivity Reactions

Yves Renaudineau*

Immunology Department Laboratory, Institut Fédératif de Biologie, Toulouse University Hospital Center, France

*Corresponding Author:
Yves Renaudineau
Immunology Department Laboratory, Institut Fédératif de Biologie, Toulouse University Hospital Center, France

Received: 02-May-2023, Manuscript No. fmijcr-23-101183; Editor assigned: 04- May-2023, Pre-QC No. fmijcr-23-101183 (PQ); Reviewed: 18-May-2023, QC No. fmijcr-23-101183; Revised: 23-May- 2023, Manuscript No. fmijcr-23-101183 (R); Published: 29-May-2023, DOI: 10.37532/1758-4272.2023.18 (5).120-122


Immunopathology is a branch of medicine and pathology that focuses on understanding the pathological processes associated with the immune system. It investigates the complex interactions between the immune system and various diseases, aiming to elucidate the mechanisms underlying immune dysregulation and its contribution to disease development and progression. This abstract provides an overview of the fundamental principles and key aspects of immunopathology. It begins by discussing the essential components of the immune system and its critical functions in maintaining homeostasis and defending the body against pathogens. Next, it explores the concept of immune dysregulation, wherein the immune system either becomes overactive or fails to respond adequately, leading to detrimental effects on the host. The abstract then highlights the major immunopathological processes observed in various diseases, including autoimmune disorders, allergies, immunodeficiencies, and chronic inflammatory conditions. It discusses the role of genetic and environmental factors in triggering immune-mediated diseases and emphasizes the importance of immune cell dysfunction, such as aberrant activation or impaired regulation, in disease pathogenesis. Furthermore, the abstract addresses the diagnostic and therapeutic implications of immunopathology. It emphasizes the significance of accurate and timely diagnosis through comprehensive immunological testing, including serological and molecular techniques. It also discusses the development and application of targeted immunotherapies aimed at restoring immune balance and modulating immune responses in a disease-specific manner. Finally, the abstract concludes by highlighting the emerging trends and future directions in immunopathology research. It underscores the importance of multidisciplinary collaborations and advances in technologies, such as high-throughput sequencing and single-cell analysis, in unraveling the complexities of immune-mediated diseases and developing personalized therapeutic strategies.


COVID-19 • Immune system diseases • Spike • IGRA • Antibody • Systemic lupus erythematosus • Multiple sclerosis • Vasculitis • Sarcoidosis • Glucocorticoids


The human immune system is a remarkable network of cells, tissues, and organs that work together to protect the body against harmful pathogens and foreign substances. It is a finely tuned system that maintains a delicate balance between effective defense and selftolerance. However, in certain circumstances, the immune system can become dysregulated, leading to immunopathology, a field of study that focuses on the understanding of immune-mediated diseases and disorders. Immunopathology explores the intricate mechanisms behind these conditions and seeks to develop better diagnostic tools, treatments, and preventive strategies. In this article, we will delve into the world of immunopathology, examining its significance, key principles, and notable diseases. Immunopathology is a branch of medical science that investigates the processes and mechanisms underlying immune responses in relation to disease development and progression [1]. It focuses on understanding how the immune system, which is designed to protect the body against harmful invaders, can sometimes malfunction and contribute to various pathological conditions. The immune system is a complex network of cells, tissues, and organs that work together to identify and eliminate foreign substances, such as bacteria, viruses, and parasites, as well as abnormal cells, such as cancer cells. It achieves this through a coordinated series of events, including the recognition of antigens (molecules on the surface of pathogens or abnormal cells) by immune cells, the activation of immune responses, and the deployment of effector mechanisms to eliminate the threat. However, in certain situations, the immune system can become dysregulated, leading to immunopathological disorders. These disorders can manifest in different ways, ranging from allergies and autoimmune diseases, where the immune system overreacts to harmless substances or attacks the body's own cells and tissues, respectively, to immunodeficiency disorders, where the immune system fails to adequately protect the body against infections. Researchers in the field of immunopathology investigate the cellular and molecular basis of immune dysregulation, seeking to unravel the intricate interactions between immune cells, signaling molecules, and target tissues. By deciphering these mechanisms, scientists aim to identify potential therapeutic targets and develop novel approaches for managing immunopathological conditions. Moreover, immunopathology plays a pivotal role in the field of transplantation medicine [2,3]. Transplants often face the challenge of immune rejection, where the recipient's immune system recognizes the transplanted organ or tissue as foreign and mounts an immune response against it. Understanding the immunological processes underlying transplant rejection is crucial for developing strategies to prevent or minimize this complication.

Material and Methods

Immunopathology involves the study of how the immune system responds to various stimuli and how this response can lead to the development of diseases. It encompasses both the aberrant immune responses that result in hypersensitivity, autoimmune disorders, and immunodeficiency, as well as the immune response to infections, tumors, and transplants.

Hypersensitivity reactions

Hypersensitivity reactions occur when the immune system overreacts to harmless substances, such as pollen, certain foods, or drugs. These reactions are categorized into four types:

Type I (Immediate hypersensitivity): This type of hypersensitivity involves the rapid release of mediators, such as histamine, in response to an allergen. Examples include allergic rhinitis, asthma, and anaphylaxis.

Type II (Cytotoxic hypersensitivity): In this type, antibodies produced by the immune system bind to antigens on the surface of cells, leading to their destruction. Autoimmune haemolytic anemia and certain drug reactions are examples of type II hypersensitivity [4, 5].

Type III (Immune complex-mediated hypersensitivity): Type III reactions occur when immune complexes, consisting of antigen-antibody aggregates, accumulate in tissues and trigger inflammation. Diseases like systemic lupus erythematosus and rheumatoid arthritis fall under this category.

Type IV (Delayed-type hypersensitivity): Unlike the previous types, type IV hypersensitivity is cell-mediated rather than antibody-mediated. It typically manifests as a delayed reaction, appearing 24 to 72 hours after exposure to an antigen. Examples include contact dermatitis and tuberculin skin tests.

Autoimmune disorders

Autoimmune disorders arise when the immune system mistakenly recognizes self-antigens as foreign and launches an immune response against the body's own tissues. The exact cause of autoimmune diseases is not fully understood, but genetic predisposition, environmental factors, and dysregulation of the immune system play significant roles. Some well-known autoimmune diseases include rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and type 1 diabetes. These conditions can affect multiple organs and tissues, leading to chronic inflammation and tissue damage [6, 7].

Immunodeficiency disorders

Immunodeficiency disorders are characterized by defects in the immune system, resulting in an increased susceptibility to infections. They can be primary (congenital) or acquired (secondary). Primary immunodeficiency’s are usually genetic and are present from birth, while acquired immunodeficiencies can occur due to infections, malnutrition, certain medications, or diseases like HIV/AIDS. Examples of primary immunodeficiencies include severe combined immunodeficiency (SCID), common variable immunodeficiency (CVID), and X-linked agammaglobulinemia (XLA). Acquired immunodeficiencies may arise from conditions such as chemotherapy-induced immunosuppression or organ transplantation.

Immunopathology and cancer

The immune system plays a crucial role in recognizing and eliminating abnormal cells, including cancer cells. However, in some cases


Immunopathology is a multidisciplinary field that combines immunology, pathology, and clinical medicine to study the aberrant immune responses associated with various diseases. By elucidating the underlying mechanisms of immunopathological conditions, researchers strive to improve diagnostic accuracy, develop targeted therapies, and ultimately enhance patient outcomes.

Immunopathology is a fascinating field of study that focuses on understanding the complex interactions between the immune system and disease processes. By investigating the dysregulation of immune responses, researchers and clinicians gain valuable insights into the mechanisms underlying various diseases [8].

Through the advancements in immunology and molecular biology, we have made significant progress in unraveling the intricate interplay between the immune system and pathological conditions. Immunopathology has shed light on the pathogenesis of numerous disorders, including autoimmune diseases, allergies, infections, and cancer. Immunopathology has also played a crucial role in the development of diagnostic tools, therapeutic strategies, and preventive measures. By identifying specific immune markers and patterns of immune dysregulation, clinicians can better diagnose and monitor diseases, while immunotherapies have revolutionized treatment options for conditions such as cancer and autoimmune disorders. Moreover, immunopathology research has provided a deeper understanding of the immune system's role in host defense, tissue repair, and maintenance of homeostasis. By deciphering the mechanisms of immune activation and regulation, scientists are uncovering new targets for drug development and immunomodulatory therapies [9].

However, there are still many challenges and unanswered questions in the field of immunopathology. The complexity of the immune system and its interactions with various cell types, signaling molecules, and genetic factors continue to present hurdles in fully understanding disease pathogenesis and developing effective treatments. Additionally, the individual variability in immune responses and the potential for immune-related adverse events necessitate further research for personalized and tailored approaches.

Immunopathology is an ever-evolving field that holds immense promise for improving human health. By unraveling the intricate workings of the immune system and its dysregulation in diseases, we are moving closer to more precise diagnostics, targeted therapeutics, and personalized medicine. Continued research and collaboration across disciplines will undoubtedly bring about further breakthroughs in immunopathology, ultimately leading to better patient outcomes and a deeper appreciation of the fascinating complexities of the human immune system [10].

Conflict of Interest





  1. Little PJ, Drennon KD, Tannock LR et al. Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP. Arch Physiol Biochem. 114(2), 120-126 (2008).
  2. Indexed at, Google Scholar, Crossref

  3. Tomlin JL, Sturgeon C, Pead MJ et al. Use of the bisphosphonate drug alendronate for palliative management of osteosarcoma in two dogs. Vet Rec. 147(5), 129-132 (2000).
  4. Indexed at, Google Scholar, Crossref

  5. Psychas V, Loukopoulos P, Polizopoulou ZS et al. Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog. J Vet Sci. 10(1), 81-83 (2009).
  6. Indexed at, Google Scholar, Crossref

  7. Loukopoulos P, Thornton JR, Robinson WF. Clinical and pathologic relevance of p53 index in canine osseous tumors. Vet Pathol. 40(3), 237-248 (2003).
  8. Indexed at, Google Scholar, Crossref

  9. Bech-Nielsen S, Haskins ME. Frequency of osteosarcoma among first-degree relatives of St Bernard dogs. J Natl Cancer Inst. 60(2), 349-353 (1978).
  10. Indexed at, Google Scholar, Crossref

  11. Wilkins RM, Cullen JW, Odom L et al. Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity. Ann Surg Oncol. 10(5), 498-507 (2003).
  12. Indexed at, Google Scholar, Crossref

  13. Kundu ZS. Classification, imaging, biopsy and staging of osteosarcoma. Indian J Orthop. 48(3), 238-246 (2014).
  14. Indexed at, Google Scholar, Crossref

  15. Papalas JA, Balmer NN, Wallace C, et al. Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review. Am J Dermatopathol. 31(4), 379-383 (2009).
  16. Indexed at, Google Scholar, Crossref

  17. Gelberg KH, Fitzgerald EF, Hwang SA et al. Fluoride exposure and childhood osteosarcoma: a case-control study. Am J Public Health. 85(12), 1678-1683 (1995).
  18. Indexed at, Google Scholar, Crossref

  19. Luetke A, Meyers PA, Lewis A et al. Osteosarcoma treatment where do we stand a state of the art review. Cancer Treat Rev. 40(4), 523-532 (2014).
  20. Indexed at, Google Scholar, Crossref

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