Xenobiotic Metabolism Scholarly Peer-Review Journal

 Drug disposition is a general term that encompasses the four processes that determine drug and metabolite concentrations in plasma, in tissue, and within cells: absorption, distribution, metabolism, and excretion. Metabolism is generally accomplished by phase I enzymes that generate more polar metabolites; the liver is the site of most drug metabolism, although some can occur in extrahepatic loci, such as the gut, kidney, or plasma. A knowledge of drugs plays a very vital and central role in the deposition of the fate drug  throughout  the research and development of pharmaceutical science. These studies aid within the discovery and selection of latest chemical entities, support safety assessment, and are critical in defining conditions for safe and effective use in patients. ADME studies provide the only basis for critical judgments from situations where the behavior of the drug is understood to those where it is unknown: this is most important in bridging from animal studies to the human situation. This presentation is intended to provide an introductory overview of the life cycle of a drug in the animal body and indicates the significance of such information for a full understanding of mechanisms of action and toxicity. Thus the deposition of drug is very important part

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