Advanced Materials Science Research

Radioresistance Research Articles

Cancer stems from the accumulation of genetic mutations in normal cells and from aberrant epigenetic modifications. Cancer stem cells (CSCs) have been identified as a special tumorigenic population of tumor mass cells capable of self-renewing and differentiating themselves. The existence and nature of CSCs has served as one of the most controversial topics in the field of cancer biology over the past few years; however, there is an abundance of evidence that demonstrates their existence more recently.It is believed that CSCs are responsible for resistance to conventional therapies, such as radiation therapy that contributes to uncontrolled tumor growth, metastasis, and subsequent patient death. In this review , we summarize the mechanism(s) by which CSCs are radioresistant, including their increased response to DNA damage, the status of the cell cycle and the role of the CSC niche.

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