Pancreatic Islets

 The pancreatic islets or islets of Langerhans are the areas of the pancreas that contain its endocrine (hormone-creating) cells, found in 1869 by German obsessive anatomist Paul Langerhans. The pancreatic islets comprise 1 to 2% of the pancreas volume and get 10–15% of its blood stream. The pancreatic islets are organized in thickness courses all through the human pancreas, and are significant in the digestion of glucose. Countless G protein-coupled receptors (GPCRs) direct the discharge of insulin, glucagon and somatostatin from pancreatic islets and a portion of these GPCRs are the objectives of medications used to treat type-2 diabetes (ref GLP-1 receptor agonists, DPPIV inhibitors).

 

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