Mycobacterium Bovis Genome
Mycobacterium bovis is the causal agent of
tuberculosis in a variety of creature
species and man, with worldwide yearly losses to farming of $3 billion. The human weight of
tuberculosis caused by the bovine tubercle bacillus is still mainly unknown. M. bovis was also the progenitor for the M. bovis bacillus Calmette–Guérin
vaccine damage, the most broadly used human
vaccine. Here we describe the 4,345,492-bp
genome series of M. bovis AF2122/97 and its contrast with the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Noticeably, the
genome series of M. bovis is >99.95% identical to that of M. tuberculosis, but
elimination of genetic
information has led to a concentrated
genome size. Comparison with M. leprae reveals a number of common
gene dead, suggesting the taking away of functional redundancy.
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