Mycobacterium Bovis Genome
Mycobacterium bovis is the causal agent of tuberculosis
in a variety of creature species
and man, with worldwide yearly losses to farming of $3 billion. The human weight of tuberculosis
caused by the bovine tubercle bacillus is still mainly unknown. M. bovis was also the progenitor for the M. bovis bacillus Calmette–Guérin vaccine
damage, the most broadly used human vaccine.
Here we describe the 4,345,492-bp genome
series of M. bovis AF2122/97 and its contrast with the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Noticeably, the genome
series of M. bovis is >99.95% identical to that of M. tuberculosis, but elimination
of genetic information
has led to a concentrated genome
size. Comparison with M. leprae reveals a number of common gene
dead, suggesting the taking away of functional redundancy.
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