Research on Chronic Diseases

McCune Albright Syndrome Impact Factor

 McCune-Albright syndrome is a condition that affects the bones, skin and other (endocrine) tissues that contain hormones. Persons with McCune-Albright syndrome develop areas in their bones with an irregular scar-like (fibrous) tissue, a disorder called polyostotic fibrous dysplasia. Polyostotic means the abnormal areas (lesions) in many bones can occur; they are quite often constrained to one part of the body. McCune-Albright syndrome (MAS) is triggered in the GNAS gene by somatic mutations. This gene encodes a part of a protein that controls hormone production by controlling several cell functions. GNAS mutations that produces MAS protein which always keeps the enzyme adenylate cyclase in ON condition. Your child doctor will do a full medical evaluation to check for cafe-au-lait spots and other McCune-Albright syndrome symptoms.   

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