Research on Chronic Diseases

Leiomyomas Health Impact Factor

 Leiomyomas are an oestrogen- and progesterone-dependent tumour that contains slowly proliferating smooth muscle cells surrounded by abundant extracellular matrix. An affected uterus may contain multiple Leiomyomas that change greatly in size and should exceed 20 cm in diameter. Molecular analyses have revealed that Leiomyomas harbour mutually exclusive driver mutations. the foremost frequent of those are mediator complex subunit 12 mutations and high mobility group AT-hook 2 translocations, which affect approximately 80% and 10% of uterine Leiomyomas, respectively. Heterozygous germline mutations within the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) cause hereditary Leiomyomatosis and renal cell cancer (HLRCC) syndrome, characterised by predisposition to type 2 papillary renal cell carcinoma, also as uterine and cutaneous Leiomyomas  

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