Neuroscience and Psychiatry: Open Access

Hereditary Spastic Paraplegia Research Articles

 Hereditary spastic paraplegia (HSP) is a group of hereditary, neurological, degenerative and disorders that primarily affect the upper motor neurons. Upper motor neurons in the spinal cord and brain Provide signals to the lower motor neurons, which in turn carry messages to the lower motor neurons muscles.Symptoms gradually get worse over time. It's also known as familial spastic paraparesis or Strümpell-Lorrain syndrome. It's difficult to know exactly how many people have hereditary spastic paraplegia because it's often misdiagnosed. Estimates range from 1 in 11,000 people to 1 in 77,000 people.The prognosis for individuals with HSP varies Some individuals are very disabled and others have only mild disability. The majority of individuals with uncomplicated HSP have a normal life expectancy. ... The NINDS supports research on genetic disorders such as HSP. The main symptoms of pure hereditary spastic paraplegia are: 1.a gradual weakness in the legs,2.increased muscle tone and stiffness (spasticity),3.problems peeing – such as an urgent need to pee, even when the bladder is not full,4.a lack of sensation in the feet (sometimes).Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and spasticity (stiffness) of the legs. ... HSP is usually diagnosed by a neurological review and testing to rule out other disorders.  

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