Annals of Clinical Trials and Vaccines Research

Glycomics & Lipidomics

 Lipids are complex polymer biomolecules that contain hydrocarbons and are strictly hydrophobic, meaning they do not interact with or dissolve in water. They are key players in metabolic regulation  acting at the cellular level through to an entire organism’s energy control and signaling pathways. Examples of lipids include oils, fats, fat-soluble vitamins, hormones, lipoproteins and lipid droplets.   “Lipidomics is end point research. If you compare it to, for example, genomics, which is interested in the genes that are almost fixed from birth, lipids on the other hand are a variant of metabolism or part of the metabolism. They change rather continuously as they are influenced by various states, not just because of the lipids you consume as part of your diet, but through disease also,” says Dr. Christian Klose, Head of Research and Development at Lipotype GmbH. Changes in lipid structure, function and expression can induce diseases such as metabolic disorders, cancer and cardiovascular disease; this is not new knowledge. However, the advanced tools to study and obtain in depth analysis of lipids at the molecular level simply have not been available. There is now the potential to identify previously unknown disease biomarkers, improve the diagnosis of lipid-related disease, and develop novel pharmacological therapeutics, further opening the door to personalized medicine. 

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