ISSN: 2048-9145

Pharmaceutical Bioprocessing

Extracellular Proteases Scholarly Peer-review Journal

 One of the key targets of drug development is proteases. Extracellular proteases are a complex and heterogeneous enzyme family that carries many important biological functions. This review explores the vasculature-related extracellular proteases, their roles and how protease disorders can lead to plaque formation, including chronic atherosclerosis, acute coronary syndromes, restenosis, and vascular remodelling. Extracellular proteases (ECPs) in many pathophysiological processes, including cancer, cardiovascular disorders, and inflammatory, pulmonary, and parodontal diseases, due to their differential expression. Several new ECP inhibitors are currently under clinical review and a significant rise in new protease inhibition-based therapies can be predicted in the coming years. Beyond directly blocking a specific protease function, differential expression in disease states may be used to deliver therapeutic or imaging agents selectively.  

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