Drug Delivery Systems Leading Journals
Drug delivery has the potential to have a tremendous impact on treatment of retinal diseases. There are a large number of
drugs that are reasonably effective to treat retinal conditions, but those
drugs are limited by delivery issues such as the need to have the molecule cross the blood–eye barrier, be present for long times, or the need to mitigate side-effects. The challenges of having
drugs at a physiologically relevant concentration for extended periods or in a localized delivery system are challenges that can be solved with
drug delivery technology, whether it is using cellular delivery systems, microelectromechanical (MEMs)-based devices, polymer matrices, or
gene delivery systems. Colonic
drug delivery can be used to treat various types of diseases. Therefore, the best candidates for colon targeting are active agents that display less absorption from the upper portion of the gastrointestinal tract. Colonic-targeted
drug delivery is useful for the treatment of inflammatory bowel diseases. In this case, the systems have been developed using pH-dependent delivery, enzyme-dependent delivery (for prodrugs, matrices, and coatings), pulsatile time-dependent delivery, and pressure-dependent delivery approaches Nowadays, some of these approaches are being used together. It is possible to combine pH and
microbial dependence with pulsatile time delivery. For example, a tablet core of lactulose coated with an acid-soluble polymer (Eudragit E) is recoated with an enteric polymer (Eudragit L). This last coating protects the tablet from the upper part of the gastrointestinal tract and dissolves in the small intestine.
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