Advanced Materials Science Research

Deciphering Secretomes

 The cell secretome is a series of proteins formed by transmembrane proteins (TM) and proteins synthesized into the extracellular space by cells. Secretory proteins make up a large portion (~13-20 per cent) of the human proteome. Throughout cell migration, cell signaling and contact, the secretory proteins play important roles. There are plenty of methodologies available such as Gene Expression Serial Analysis (SAGE), DNA microarrays, antibody arrays and bead-based arrays, electron microscopy, RNA sequencing and yeast, bacteria and mammal secretion traps to classify cell secretions. There are also advantages and disadvantages of using all of the above approaches. These proteins plays a major role in the formation of human proteome.  

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