Editorial - Journal of Pediatric Neurological Disorders (2023) Volume 6, Issue 2

In children and adolescents with Multisystem Inflammatory Syndrome in Children (MISC): the significance of brain and heart imaging

Emir Acarbay*

Department of Neurophysiology, Ankara University, Turkey

*Corresponding Author:
Emir Acarbay
Department of Neurophysiology, Ankara University, Turkey
E-mail: acarbay@au.ac.tk

Received: 01-Apr-2023, Manuscript No. pnn-23-97100; Editor assigned: 03-Apr-2023, PreQC No. pnn-23- 97100(PQ); Reviewed: 17-Apr-2023, QC No. pnn-23-97100; Revised: 20- Apr-2023, Manuscript No. pnn-23- 97100; Published: 27-Apr-2023, DOI: 10.37532/pnn.2023.6(2).45-47


Multisystem Inflammatory Syndrome in Children (MIS-C), which was recently discovered in a small number of SARS-CoV-2-infected children, is similar to Kawasaki disease (KD), an unidentified medium vessel vacuity. 68% of patients with MIS-C will require admission to the intensive care unit, in contrast to acute COVID-19 infection, which is typically mild in children. Myocarditis and coronary artery ectasia/aneurysm are among the most common cardiovascular complications in MIS-C; consequently, close clinical evaluation is required at diagnosis and during follow-up. Echocardiography is the foundation methodology for myocardial capability and coronary supply route assessment in the intense stage. During convalescence and in adolescents, where echocardiography may not provide adequate images, cardiovascular magnetic resonance (CMR) detects diffuse myocardial inflammation, including oedema and fibrosis, myocardial perfusion, and coronary artery anatomy. MIS-C involves the brain less frequently than cardiovascular disease does. However, given that we do not yet know how it affects brain development, it is not uncommon and should be monitored through clinical evaluation and brain magnetic resonance imaging (MRI). T2- hyperintense lesions with restricted diffusion and bilateral thalamic lesions are seen on the MIS-C brain MRI. To finish up, MIS-C is a multisystem infection influencing numerous essential organs, like heart and cerebrum. Physicians will be able to prevent the terrible complications of MIS-C with the assistance of clinical awareness, the utilization of cuttingedge, high-tech imaging modalities, and cutting-edge treatment protocols that include medication for support and anti-inflammatory purposes.


Multisystem inflammatory syndrome • Kawasaki disease • Myocarditis • Magnetic resonance imaging • Bilateral thalamic lesions


Multisystem Incendiary Disorder (MIS-C) has been as of late detailed in a minority of kids impacted by SARS-CoV-2. Kawasaki disease (KD), a medium vessel vasculitis of unknown cause that mostly affects children under the age of five, is a MIS-C clone. A few terminologies have been utilized to depict this illness including Kawasaki-like condition (KLS), abnormal Kawasaki disease, inadequate Kawasaki illness, SARS-CoV-2-initiated Kawasaki-like Hyper-fiery Disorder (SCiKHDisorder) and Kawa-Coronavirus. The disease has been referred to as MIS-C by the United States Centers for Disease Control and Prevention (CDC), Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19 by the World Health Organization, and PIMS-TS by the Royal College of Paediatrics and Child Health. Pediatric Coronavirus patients generally present with gentle side effects including hack, fever, sore throat and the runs; yet, low respiratory parcel symptomatology is somewhat unusual, contrasted with grown-ups. Fortunately, children only account for 1–5% of COVID-19 cases, and more than 80% of those cases are asymptomatic or mild. Children also have significantly lower COVID-19 mortality rates than adults (0.1% versus 5–15%). Conversely to intense Coronavirus contamination, which is gentle in youngsters, 68% of MIS-C patients present a very extreme condition and need concentrated care support, due to cardiovascular inconveniences [1,2]. The following clinical and laboratory characteristics set MIS-C and KD apart: 1) Gastrointestinal ntanglements, neurological side effects, shock and coagulopathy are more normal in MIS-C, yet all the same strangein exemplary KD. (2) While MIS-C has been reported more frequently in patients of African, Hispanic, or Latino descent, classic KD is prevalent in North East Asians. 3) KD is common in children younger than five years old, whereas MIS-C is more common in children older than five years old. 4) In MIS-C, low platelets, lymphopenia, and high C-reactive protein (CRP) levels are common, but KD is rather uncommon. MIS-C is a serious condition, similar to other hyper-inflammatory syndromes in children, such as KD shock syndrome, toxic shock syndrome, and macrophage activation syndrome, despite the fact that COVID-19 is mild in children [3,4].

Contribution of Brain in MIS-C

Mental adjustment has been portrayed during Coronavirus. However, cases of severe encephalopathy in MIS-C patients are extremely uncommon. Ischemic infarcts occurred in 31% of adults with COVID-19 and neurologic symptoms, intracranial hemorrhage occurred in 6%, and nonspecific T2/fluid-attenuated inversion recovery hyper intensity with restricted diffusion occurred in a small percentage. The update of 187 youngsters from six ongoing reports of MIS-C showed that these youngsters had a suddenly high frequency (34%) of neurological contribution. In children with MIS-C, the pathophysiologic mechanism of neurologic complications is still a mystery. The thromboembolic cerebrovascular events that adults with COVID-19 experience may have a different mechanism in MIS-C. Although the pathophysiologic mechanism of MIS-C meningoencephalitis is still unknown, it may be related to neuronal cell edema caused by cytokine storm syndrome, which occurs when monocytes, macrophages, and T cells overreact to SARSCoV- 2 infection and release interleukins-6 (IL-6). Despite the fact that adults have also experienced metabolic encephalopathy or direct invasion of the central nervous system (CNS) as a result of severe hypoxia, however, the absence of a positive SARS-CoV-2 RT-PCR test in the cerebrospinal fluid (CSF) and the mild lung involvement in these cases do not support the hypothesis of COVID-19 encephalopathy. Last but not least, reversible splenial lesion syndrome (RESLES) ought to be talked about. This is characterized by a temporary lesion in the corpus callosum's spleen caused by encephalitis, seizures, antiepileptic drug withdrawal, or metabolic problems. RESLES with gentle encephalitis/ encephalopathy furthermore, reversible splenial injury has been characterized as a particular disorder, related with different viral diseases [5,6].

Cardiovascular Magnetic Resonance

CMR has the unique capability of providing a radiation-free examination of coronary arteries, biventricular function, and tissue characterization in a single procedure that is highly reproducible. The Lake Louis (LL) criteria are used to make the diagnosis of myocarditis, which is the main lesion in MIS-C. In diagnosing myocarditis, LL is 78 percent accurate. Edema on T2-weighted images, hyperemia and early capillary leakage on T1-weighted early gadolinium enhancement images (EGE), and fibrosis on late gadolinium enhanced images (LGE) are all considered LL criteria. When two out of three indices are abnormal, the LL criteria have a high positive predictive value and high specificity. Alterations caused by myocarditis may precede multiple LGE patterns, are typically confined to the sub-epicardial or intramural regions of the left ventricle (LV), and frequently occur in the basal to mid-inferolateral wall. LGE-positive patients are at expanded chance of unfriendly heart occasions, while LGE-negative patients normally have a superb guess, autonomously of their symptomatology [7].

Impression of CMR and Brain MRI in the MIS‑C Patients

The patient's future will be significantly impacted by the severity of the cardiac involvement. Myocardial capability decay might prompt future obstinate cardiovascular breakdown, assuming it is not entirely treated. Besides, the determination of myocardial irritation might recommend treatment of the immune modulatory prescription. At long last, the presence of CAA requests persistent appraisal of coronary supply routes life systems and myocardial perfusion assessment to survey the need of expected mediation. When it comes to the evaluation of neurologic deficits following MIS-C, brain MRI has significant value and can direct subsequent treatment [8-10].


MIS-C affects numerous vital organs, including the heart and brain, despite its rarity. The intensive care unit may be required for patients with MIS-C, who should be treated in the hospital. Both supportive and anti-inflammatory medications' effects on cardiovascular disease may be successfully guided by imaging modalities like echocardiography and Computed Magnetic Resonance (CMR). Additionally, brain MRI can reveal brain involvement, which should be appropriately treated and may have significant acute and follow-up clinical implications.


  1. Parri N, Lenge M, Buonsenso D. Children with Covid 19 in pediatric emergency departments in Italy. N Engl J Med. 383, 187-190 (2020).
  2. Indexed at, Crossref, Google Scholar

  3. Radia T, Williams N, Agrawal P et al. Multi-system inflammatory syndrome in children & adolescents (MIS-C): a systematic review of clinical features and presentation. Paediatr Respir Rev. (2020)
  4. Indexed at, Crossref, Google Scholar

  5. Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children (MIS-C) | CDC. Accessed 6 Feb 2021
  6. Google Scholar

  7. Han SB, Lee SY. Macrophage activation syndrome in children with Kawasaki disease: diagnostic and therapeutic approaches. World J Pediatr. 16, 566-574 (2020).
  8. Indexed at, Crossref, Google Scholar

  9.  Kabeerdoss J, Pilania RK, Karkhele R et al. Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatol Int. 41, 19-32 (2021).
  10. Indexed at, Crossref, Google Scholar

  11. Gasparyan AY, Ayvazyan L, Blackmore H et al. Writing a narrative biomedical review: considerations for authors, peerreviewers, and editors. Rheumatol Int. 31, 1409-1417 (2011).
  12. Indexed at, Crossref, Google Scholar

  13. Pouletty M, Borocco C, Ouldali N. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19):a multicentre cohort. Ann Rheum Dis. 79, 999-1006 (2020).
  14. Indexed at, Crossref, Google Scholar

  15. Belhadjer Z, Méot M, Bajolle F et al. Acute heart failure in multisystem inflammatory syndrome in children in the context of global SARS-CoV-2 pandemic. Circulation. 142, 429-436 (2020).
  16. Indexed at, Crossref, Google Scholar

  17. Pilania RK, Bhattarai D, Singh S. Controversies in diagnosis and management of Kawasaki disease. World J Clin Pediatr. 7, 27-35 (2018).
  18. Indexed at, Crossref, Google Scholar

  19. Cheung EW, Zachariah P, Gorelik M. Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents in New York City. J Am Med Assoc. 324, 294-296 (2020).
  20. Indexed at, Crossref, Google Scholar