All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Towards a dynamical network view of brain ischemia and reperfusion. Part I: background and preliminaries

Author(s): Donald J. DeGracia

The general failure of neuroprotectants in clinical trials of ischemic stroke points to the possibility of a fundamen-tal blind spot in the current conception of ischemic brain injury, the “ischemic cascade”. This is the first in a se-ries of four papers whose purpose is to work towards a revision of the concept of brain ischemia by applying network concepts to develop a bistable model of brain ischemia. This first paper sets the stage for developing the bistable model of brain ischemia. Necessary background in network theory is introduced using examples from developmental biology which, perhaps surprisingly, can be adapted to brain ischemia with only minor mod-ification. Then, to move towards a network model, we extract two core generalizations about brain ischemia from the mass of empirical data. First, we conclude that all changes induced in the brain by ischemia can be classified as either damage mechanisms that contribute to cell death, or stress responses that contribute to cell survival. Second, we move towards formalizing the idea of the “amount of ischemia”, I, as a continuous, non-negative, monotonically increasing quantity. These two generalizations are necessary precursors to reformulat-ing brain ischemia as a bistable network.

Share this
izmir bayan escort escort izmir bursa escort antalya escort kızlar izmir escort porno porno indir porno izle escort bartın escort burdur escort eskişehir havalandırma sistemleri porno izmir escort bursa escort porno izle indir izmir escort bayan