Abstract

The Role of Gut Microbiota in the Pathogenesis of Inflammatory Rheumatic Diseases: Implications for Therapy

Author(s): Robin Christensen*

Recent studies have revealed an intricate link between gut microbiota and inflammatory rheumatic diseases (IRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). Gut dysbiosis, characterized by an imbalance in the microbial community, is increasingly recognized as a contributing factor to the pathogenesis of these diseases. Inflammatory rheumatic diseases are associated with altered gut microbiota composition, which may influence systemic inflammation, immune regulation, and disease progression. This review explores the role of gut microbiota in the pathogenesis of IRD, highlighting the mechanisms through which microbial imbalances may contribute to disease onset and flares. Additionally, the potential therapeutic implications of modulating the gut microbiome through diet, probiotics, prebiotics, and fecal microbiota transplantation are discussed. Understanding the complex interaction between the gut microbiota and host immunity may open novel avenues for the treatment and prevention of IRD.