The effect of propolis and honey lotion on improving diabetic foot ulcers

Author(s): Elham Rasoulian, Mitra Zandi1*, Gholamreza Esmaeeli Djavid & Azam Malekiam

Background and objective: Diabetic foot ulcer, as one of the most important complications of diabetes, is a major problem in the management of patients with diabetes. In many cases, diabetic wounds do not respond to the usual treatments and lead to amputation. In addition, it imposes a high cost on the patient and the community. Propolis is a product that produced by bees to protect the hive from pathogens. Propolis is a resin material processed using salivary glands from the gums of various plants (some species are more commonly used) by worker bees. Propolis has multiple properties that are useful in the treatment of wounds, including diabetic wounds, due to its anti-inflammatory, antioxidant and antimicrobial properties. The authors have performed a study in order to evaluate the efficacy of propolis on improving diabetic foot ulcers. The comparison between the control group and the intervention group shows that the treatment effect of the intervention group (Propolis) is better. Stusies have been shown that the medicinal properties of honey and propolis. Therefore, the aim of this study was to determine the effect of Propolis and honey lotion on the healing of diabetic foot ulcers. Materials and methods: In this study, the clinical trials of 60 patients with diabetic foot ulcers were randomly assigned into the study based on the Wenger criteria. Wound swab was done for culture in the both group and antibiotics were given accordingly. Both group had daily dressings. Patients were evaluated for 4 weeks. Wound area measurements were performed on the first day and four weeks after the intervention. Results: Differences in mean wound size in control and intervention groups prior to intervention were not significant using the Mann-Whitney test (P=0.068). However, changes in the mean wound size before and after the intervention was statistically significant in the two intervention and control groups using the Mann-Whitney test (p. Less than 0.001). This indicates the effectiveness of the intervention in reducing the size of the wound in patients with diabetes. This showed remarkable signs of improvement at the end of the 30th days. Conclusion: It is expected that using propolis and honey lotion could better improve diabetic foot ulcers and accelerate wound healing.

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