ISSN: 1758-4272

International Journal of Clinical Rheumatology

Streptomyces Coelicolor Peer-review Journals

  Streptomyces coelicolor is a soil-dwelling Gram-positive bacterium that belongs to the genus Streptomyces.Streptomyces coelicolor has one linear chromosome and two plasmids, one that is linear and one that is circular. The linear chromosome was sequenced from overlapping clones of the species, most of which were cosmids, that did not contain the two plasmids. This chromosome contains 8,667,507 base pairs, and was the largest bacterial genome sequenced at the time.live in the soil, where nutrient conditions can change dramatically. As a result, this bacteria is capable of living on may different carbon sources including "glycerol, L-arabinose, D-arabitol, salicin, cellobiose, lactose, maltose,alanine, asparagine, glutamate, glycine, histidine, isoleucine, leucine, lysine, methionine, proline, serine, threonine, tryptophan and valine".Streptomyces have a life cycle similar to that of fungi. The cycle starts with growth of vegetative mycelium from a spore, followed by aerial mycelium, and, then, spores. This complex lifestyle is facilitated by cell differentiation. Instead of two totally separated cells forming after cell division, chains of cells remain linked together to form a branching mycelium network.Streptomyces coelicolor and other Streptomyces species are important to soil environments because they are capable of metabolizing other organism's remains. They are especially important because they can degrade chitin and other compounds that are difficult to degrade. This ability makes them an integral part of the global carbon cycle and the Strains of S. coelicolor produce various antibiotics, including actinorhodin, methylenomycin, undecylprodigiosin,and perimycin.Certain strains of S. coelicolor can be used for heterologous protein expression.    

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