ISSN: 2048-9145

Pharmaceutical Bioprocessing

Protein Interaction Scholarly Open Access

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a results of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and therefore the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur during a cell or during a living organism during a specific biomolecular context. Proteins rarely act alone as their functions tend to be regulated. Many molecular processes within a cell are administered by molecular machines that are built from numerous protein components organized by their PPIs. These interactions structure the so-called interactomics of the organism, while aberrant PPIs are the idea of multiple aggregation-related diseases, like Creutzfeldt–Jakob, Alzheimer's diseases. PPIs are studied with many methods and from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of huge protein interaction networks – almost like metabolic or genetic/epigenetic networks – that empower the present knowledge on biochemical cascades and molecular etiology of disease, also because the discovery of putative protein targets of therapeutic interest. the entire amount of muscle proteins in mammals, including humans, exceeds that of the other protein.       

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