Journal of Biochemistry Research

Prostate-specific Antigen Journals

 Prostate cancer (PCa) is one of the most common cancers and one of the leading causes of death in industrialized countries. Serum prostate-specific antigen (PSA) is a useful biomarker for PCa screening and monitoring for disease progression of the patients. PSA was firstly detected in 1980 and is responsible for semen liquefaction and secreted into the seminal plasma. In serum, PSA occurs with different isoforms complexed by plasma proteins; 70–90% of PSA is complexed with a1 antichymotrypsin, <5% is bound inter-a-trypsin inhibitor and protein C inhibitor. Some undetectable PSA is complexed a2 macroglobulin and the remaining level of PSA (10–30%) is not bound to serum proteins and is called free PSA (fPSA).    

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