Annals of Clinical Trials and Vaccines Research

Online Journals Of Drug Discovery

 Drug discovery is the first step of the value chain that identifies new candidate therapeutics for treating or curing human diseases.It is the initial stage of biopharma research and development (R&D) and involves the identification and optimisation of potential new drugs and a preclinical in vivo validation through cell assays and animal models. Successful candidates that meet the regulatory requirements applied to drug discovery move into the clinical trial phase, where they are tested for efficacy and safety in humans. Our next report in the series examines the impact AI is having on clinical trials (Intelligent clinical trials: Transforming through engagement). Manufacturing and administration routes, low specificity and a stable shelf life, meaning they are safe and effective for large groups of people. However, low specificity can also lead to side effects, reducing the chances of success in clinical trials. Since the 1990s, scientific and technological advances have led to the discovery of larger, more complex, biological therapeutics known as biologics. In contrast to chemically synthesised small molecules, biologics are produced or isolated from living organisms and include a wide range of products such as allergenics, antisense drugs, blood and blood components, recombinant therapeutic DNA and proteins, and vaccines. Historically, the discovery of new therapeutics involved the extraction of ingredients from natural products and basic research to find potential treatments.

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