Archives of Nursing and Care

Hereditary Gastrointestinal

 Hereditary gastrointestinal (GI) cancer syndromes thanks to specific germline mutations are characterized by an increased risk of gastrointestinal tract malignancies, extra–GI tract cancers, and benign abnormalities. These syndromes include Lynch syndrome, familial adenomatous polyposis, juvenile polyposis syndrome, Peutz-Jeghers syndrome, Cowden syndrome, hereditary diffuse gastric cancer, and hereditary carcinoma. Timely identification of the responsible genes will help predict future cancer risks in these patients and their members of the family. Early detection of cancers is feasible with appropriate screening methods; risk-reducing measures will help in cancer prevention. Select malignancies and benign conditions related to these syndromes have distinctive imaging features which will aid in classifying the syndromes. Imaging also plays a pivotal role in screening and surveillance of patients yet as their at-risk relatives and is invaluable for follow-up of treated malignancies. The American College of Gastroenterology has established specific guidelines for diagnosis and management of hereditary GI cancer syndromes. Knowledge of the imaging features of varied pathologic conditions and screening strategies will guide appropriate management of patients and at-risk relations.  

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