Glycomics Impact Factor

 Glycoconjugates exert their biological functions through complicated molecular mechanisms involving each direct glycan recognition, and indirect glycan contributions to conformation and expression of the glycoconjugate. Glycans area unit directly recognized by glycan-binding proteins (GBPs) (Figure 1). Such interactions of glycans with GBPs will promote cell adhesion, cell-matrix interactions, cellular communication, conjugated protein folding, and intracellular/extracellular targeting to organelles. additionally, glycans connected to macromolecules exert management through indirect mechanisms on conjugated protein conformation, stability, oligomerization, cell surface resident time, and turnover. Most secreted and membrane proteins area unit enzymatically glycosylated on one or a lot of amino acids (Apweiler et al., 1999; Steentoft et al., 2013; Van den Steen et al., 1998; Zielinska et al., 2012; Zielinska et al., 2010), and nearly all nuclear and DNA binding proteins, living substance enzymes concerned in metabolic regulation, and a few mitochondrial proteins have the O-β-N-acetylglucosamine (O-GlcNAc) modification on Ser/Thr (Bond and Hanover, 2013; Copeland et al., 2013; Hart et al., 2011; Palaniappan et al., 2013; Lolo et al., 2012). AN rising paradigm of contemporary glycomics acknowledges that higher animals categorical a huge repertoire of glycan structures, that comprise their overall glycomes, and up to date studies area unit unexpectedly revealing that glycans contribute in each general and specific ways that to most biological regulative pathways. Thus, as may well be foretold, abnormalities in glycoconjugate synthesis or turnover area unit related to many completely different human diseases and disorders, together with the noninheritable Disorders of Glycosylation (CDGs) and Dystroglycanopathies