ISSN: 2048-9145

Pharmaceutical Bioprocessing

Enzyme-kinetics Peer Review Journals

Enzyme kinetics is the study of the enzyme-catalyzing chemical reactions. The reaction rate is calculated in enzyme kinetics, and the results of changing the reaction conditions are studied. Studying the kinetics of an enzyme in this way will reveal the catalytic function of this enzyme, its role in metabolism, how its activity is regulated and how the enzyme can be inhibited by a drug or an agonist. These mechanisms can be broken down into single and multi-substrate mechanisms. Kinetic enzyme studies which bind only one substrate, such as triosephosphate isomerase, aim to measure the affinity with which the enzyme binds this substrate and the rate of turnover. Enzyme kinetics can also show the sequence in which these substrates bind and the sequence in which products are released when enzymes bind multiple substrates, such as dihydrofolate reductase (shown right); Proteases are an example of enzymes that bind a single substrate and release multiple products that cleave one protein substratum into two polypeptide products.    

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