Annals of Clinical Trials and Vaccines Research

Drug Metabolism Top Journals

 Drug metabolism is that the metabolic breakdown of medicine by living organisms, usually through specialized enzymatic systems. Which are compounds foreign to an organism's normal biochemistry, like any drug orpoison. These pathways are a sort of biotransformation present altogether major groups of organisms and are considered to be of ancient origin. The metabolism of pharmaceutical drugs is a crucial aspect of pharmacology and medicine. The drug metabolisms are the live breakdown of the living organisms and also we can discuss them. For example, the rate of metabolism determines the duration and intensity of a drug's pharmacologic action. Drug metabolism also affects multidrug resistance in infectious diseases and in chemotherapy for cancer, and therefore the actions of some drugs as substrates or inhibitors of enzymes involved in xenobiotic metabolism are a standard reason for hazardous drug interactions. Drug metabolism is divided into three phases. In phase, I, enzymes like cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. These modified compounds are then conjugated to polar compounds in phase II reactions. These reactions are catalysed by transferase enzymes like glutathione S-transferases. Finally, in phase III clinical trial, the conjugated xenobiotics could also be further processed, before being recognised by efflux transporters and pumped out of cells.   

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