Annals of Clinical Trials and Vaccines Research

Drug Distribution Case Reports

 Drug Distribution has meant the reversible amount of drug transferred within the body from one part to another. Once a drug enters by absorption into systemic circulation it is distributed in interstitial and intracellular fluids. The organ or tissue receives varying doses of medications, and the drug persists for a variable amount of time in the various organs or tissues. The distribution of tissue doses of a drug depends on vascular permeability, cardiac output, regional tissue blood flow and perfusion rate, and drug binding to tissue and plasma proteins and lipid solubility. Drug distribution also involves the partitioning of pH.Drugs can be easily distributed in highly perfused organs such as liver, heart, and kidney. Drugs are administered in limited amounts at perfused tissues such as muscle, fat, and peripheral organs. The unbound drug contained in plasma is transferred from the plasma to the tissue when equilibrium is reached.  

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