Downs Syndrome Online Journals
Down
syndrome is brought about by an additional duplicate of the long arm of human
chromosome 21 and the expanded articulation, because of measurement, of HSA21 encoded qualities. In addition to intellectual disability, all people with Down
Syndrome build up the neuropathology of Alzheimer's disease. The amyloid antecedent protein quality, APP, that is transformed or copied in some Familial Alzheimer's Disease (FAD), is encoded by HSA21, over communicated in Down syndrome, and a contender for causing AD in Down syndrome. Nonetheless, just 50% of those with Down
syndrome will build up the AD-like dementia, proposing that extra HSA21 qualities may regulate the impacts of APP triplication, or potentially shield the Down
syndrome mind from beginning stage movement to
dementia despite neuropathology.
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