Journal of Cosmetic Science and Technology

DNA Microarray Technology Open Access Journals

Gene expression may be a sensitive indicator of toxicant exposure, disease state, and cellular metabolism and thus represents a singular way of characterizing how cells and organisms adapt to changes within the external environment. The measurement of organic phenomenon levels upon exposure to a chemical can both provide information about the mechanism of action of toxicants and form a kind of “genetic signature” from the pattern of organic phenomenon changes it elicits both in vitro and in vivo . The event of such organic phenomenon signatures would allow fast screening of unknown or suspected toxicants on the idea of their similarity to known toxicants.The possibility of analyzing the effect of chemicals and environmental stressors on an outsized number of genes during a single experiment has led to the event of the sector of toxico genomics. Proponents of toxicogenomics. The availability of the entire human genome and of the genome of several other organisms (NCBI 2005b) allows the appliance of microarray technology to many model organisms (from bacteria, to yeast, to fish) and mammalian cell lines.In this review I evaluate the potential of microarray technology for ecotoxicology. I briefly review recent applications of DNA microarray to toxicology and analyze how the sector of ecotoxicology may benefit from the experience already gained from toxicology .I describe samples of the contribution of the technique in addressing important ecotoxicology problems also as problems and limitations related to the technique. Finally, I suggest future paths for more extensive application of microarray to ecotoxicology.    

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