Advanced Materials Science Research

Cyclooxygenase

 Cyclooxygenase (COX) is a rate-limiting enzyme involved in the transformation of arachidonic acid into prostaglandin H2, a precursor to several molecules, including prostaglandins, prostacyclines and thromboxanes. The prostaglandins are autocoid mediators that affect virtually all known physiological and pathological processes by their reversible interaction with membrane receptors coupled with G-protein. Levuloglandins are a new class of products that tend to act on various proteins via permanent, covalent attachment. COX enzymes are of clinical importance because aspirin and many other non-steroidal anti-inflammatory drugs inhibit them. COX-1 has been found in the blood vessels, interstitial cells, smooth muscle cells, mesothelial cells and platelets. Conversely, COX-2 was found predominantly in many tissue parenchymal cells, with few exceptions, e.g. in the heart.

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