Current Reviews In Pharmacoproteomics
Proteomics is defined because the study of proteins and their variability in human disease states. The proteome may vary between different individuals, different organs, or maybe between
cells within the same organ in a private. Pharmacoproteomics is rapidly increasing the advancements within the sector during the techniques of proteomics are applying to develop the pharmaceutical agents. Pharmacoproteomics could also be a more functional representation of patient-to-patient variation than that provided by genotyping. Pharmacoproteomics methodology is providing an important quantitative data on protein expression patterns in response to a given pharmaceutical stimulus also as qualitative
information on post-translational modifications to each protein. This is providing an
information on signaling cascades triggered independently of protein neosynthesis and data on early cellular events just like the stimulus. Proteomes are therefore dynamic, and a given human may have a proteome with as many as two million proteins. The use of this full set of proteins to review the effect of disease or
drugs can substitute for far more complex assays in pharmacodynamics at a lower cost in time, financial output, and clinical risk. Some of the apparent advantages of studying pharmacoproteomics include the power to predict which
drugs are going to be ultimately useful in humans, by revealing the pharmacokinetics, bioavailability, metabolism, and adverse or side effects of new or novel therapeutic agents in the preclinical stage. This is made possible by the power to review how
drugs work on the extent of protein expression, while simultaneously deciphering their toxicity and resistance to their cellular mechanism of action, early within the
drug development process instead of after a protracted and dear preclinical testing phase.
High Impact List of Articles
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Intracranial Venous Sinuses Characteristics Prior To And Following Resection Of Brain Tumors
Amit Azriel, Israel Melamed, Yuval Sufaro, Avi Cohen, Mony Benifla, Nitsan Mendelson & Ilan Shelef
Research Article: Imaging in Medicine
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Intracranial Venous Sinuses Characteristics Prior To And Following Resection Of Brain Tumors
Amit Azriel, Israel Melamed, Yuval Sufaro, Avi Cohen, Mony Benifla, Nitsan Mendelson & Ilan Shelef
Research Article: Imaging in Medicine
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Imaging in Medicine
anonymous
News and Views: Imaging in Medicine
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Imaging in Medicine
anonymous
News and Views: Imaging in Medicine
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New MRI tools shed light on Parkinson's disease progress Compact MRI system in development for improved joint imaging Diffusion-weighted MRI could guide development of new and improved tumor models, Cardiac CT reveals surprising racial differences in thoracic fat measurements, Analysis of multiple Alzheimers disease biomarkers might improve chance of predicting cognitive decline, Functional MRI could predict onset of bipolar disorder in at-risk individuals
Anonymous
News and Views: Imaging in Medicine
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New MRI tools shed light on Parkinson's disease progress Compact MRI system in development for improved joint imaging Diffusion-weighted MRI could guide development of new and improved tumor models, Cardiac CT reveals surprising racial differences in thoracic fat measurements, Analysis of multiple Alzheimers disease biomarkers might improve chance of predicting cognitive decline, Functional MRI could predict onset of bipolar disorder in at-risk individuals
Anonymous
News and Views: Imaging in Medicine
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Application of ultrasound-guided wire placement in head and neck cancer biopsy: where are we now?
Dimitra Christodoulou, Jasdeep Bajwa, Gulcan Gok, Robert Hywel Thomas and David Crispin Howlett
Special Issue Article: Imaging in Medicine
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Application of ultrasound-guided wire placement in head and neck cancer biopsy: where are we now?
Dimitra Christodoulou, Jasdeep Bajwa, Gulcan Gok, Robert Hywel Thomas and David Crispin Howlett
Special Issue Article: Imaging in Medicine
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Day-to-day variation in Doppler activity in patients on stable etanercept treatment: an exploratory cohort study
Lene Terslev, Klaus Muller, Robin Christensen, Karen Ellegaard, Soren Torp Pedersen, Sif Gudbrandsdottir and Henning Bliddal
Research Article: Imaging in Medicine
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Day-to-day variation in Doppler activity in patients on stable etanercept treatment: an exploratory cohort study
Lene Terslev, Klaus Muller, Robin Christensen, Karen Ellegaard, Soren Torp Pedersen, Sif Gudbrandsdottir and Henning Bliddal
Research Article: Imaging in Medicine
Relevant Topics in General Science