Atrial Natriuretic Peptide
Atrial symptom
peptide (ANP) or chamber symptom issue (ANF) may be a symptom amide secretion secreted from the internal organ atria that in humans is encoded by the NPPA cistron.[1] symptom
peptides (ANP, BNP, and CNP) area unit a family of hormone/paracrine factors that area unit structurally connected.[2] the most operate of ANP is inflicting a discount in distended body fluid (ECF) volume by increasing excretory organ atomic number 11 excretion. ANP is synthesized and secreted by heart muscle
cells within the walls of the atria within the heart. These
cells contain volume receptors that reply to inflated stretching of the chamber wall thanks to inflated chamber blood volume.
Reduction of blood volume by ANP may end up in secondary effects like reduction of body fluid (ECF) volume (edema), improved internal organ ejection fraction with resultant improved organ insertion, attenuate force per unit area, and inflated liquid body substance K. These effects could also be dull or negated by varied counter-regulatory mechanisms operative at the same time on every of those secondary effects.
Brain symptom amide (BNP) – a misnomer; it's secreted by heart muscle
cells within the heart ventricles – is comparable to ANP in its result. It acts via an equivalent receptors as ANP will, however with 10-fold lower affinity than ANP. The biological half-life of BNP, however, is double as long as that of ANP, which of NT-proBNP is even longer, creating these
peptides higher decisions than ANP for diagnostic blood testing.
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