Annals of Clinical Trials and Vaccines Research

Translational Bioinformatics

 Translational medical research has emerged as an important theme in the last decade. Starting with top-down leadership from the National Institutes of Health and its former Director, Dr. Elias Zerhouni, and moving through academic medical centers, research institutes and industrial research and development efforts, there has been interest in more effectively moving the discoveries and innovations in the laboratory to the bedside, leading to improved diagnosis, prognosis, and treatment. Translational research encompasses many activities including the creation of medical devices, molecular diagnostics, small molecule therapeutics, biological therapeutics, vaccines, and others. One of the main targets of translation, however, is revolutionary explosion of knowledge in molecular biology, genetics, and genomics. Some believe that the tremendous progress in discovery over the last 50+ years since elucidation of the double helix structure has not translated (there's that word!) into much practical health benefit. While the accuracy of this claim can be debated, there can be no debate that our ability to measure DNA sequence ,  RNA sequence and expression, protein sequence, structure, expression and modification, and  small molecule metabolite structure, presence, and quantity has advanced rapidly and enables us to imagine fantastic new technologies in pursuit of human health.  

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